EQUILIN

Synonym(s):1,3,5(10),7-Estratetraen-3-ol-17-one;3-Hydroxy-1,3,5(10),7-estratetraen-17-one;7-Dehydroestrone

CAS NO.：474-86-2
Empirical Formula: C18H20O2
Molecular Weight: 268.35
MDL number: MFCD00046223
EINECS: 207-488-6
SAFETY DATA SHEET (SDS)
Update Date: 2024-10-28 16:48:35

What is EQUILIN?

Chemical properties

Off-White Solid

The Uses of EQUILIN

Equilin is an estrogen found in Premarin, which is a mixture of conjugated estrogens widely used in hormone replacement therapy.

Definition

ChEBI: Equilin is a 17-oxo steroid and a 3-hydroxy steroid. It derives from a hydride of an estrane.

General Description

An estrogen present in the hormone replacement therapy drug Premarin. Equilin levels are monitored in drinking water samples by LC-MS/MS using EPA method 539.

Properties of EQUILIN

Melting point:	238-240 °C(lit.)
Boiling point:	351.51°C (rough estimate)
alpha	D25 +308° (c = 2 in dioxane); D25 +325° (c = 2 in alc)
Density	1.1096 (rough estimate)
refractive index	1.4800 (estimate)
Flash point:	9℃
storage temp.	Refrigerator
solubility	Chloroform (Slightly), Dioxane (Slightly, Heated, Sonicated), DMSO (Slightly, Sonicated)
form	Solid
pka	pKa 10.26±0.04(H2O t=23±2) (Uncertain)
form	neat
color	White to off-white
Water Solubility	1.4mg/L(25 ºC)
Merck	13,3672
BRN	2624302
EPA Substance Registry System	Equilin (474-86-2)

Safety information for EQUILIN

Signal word	Warning
Pictogram(s)	Health Hazard GHS08
GHS Hazard Statements	H351:Carcinogenicity H362:Reproductive toxicity, effects on or via lactation
Precautionary Statement Codes	P202:Do not handle until all safety precautions have been read and understood. P260:Do not breathe dust/fume/gas/mist/vapours/spray. P263:Avoid contact during pregnancy/while nursing. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P308+P313:IF exposed or concerned: Get medical advice/attention.