EIPA
Synonym(s):EIPA
- CAS NO.:1154-25-2
- Empirical Formula: C11H18ClN7O
- Molecular Weight: 299.76
- MDL number: MFCD00151710
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-08-24 19:19:26
What is EIPA?
Description
Sodium-
Chemical properties
Yellow Solid
The Uses of EIPA
Selective Na+/H+ antiporter inhibitor. Selectively enhances the excretion of sodium ions without causing an increase in excretion of potassium ions
The Uses of EIPA
Selective Na+/H+ antiporter inhibitor. Selectively enhances the excretion of sodium ions without causing an increase in excretion of potassium ions.
The Uses of EIPA
5-(N-Ethyl-N-isopropyl)amiloride has been used:
- as a supplement in endothelial cell growth medium to incubate human lung microvascular endothelial cell
- in Pluronic F-127 stock solution for Drosophila larval live-imaging
- in choline chloride solution as an experimental perfusate, to study the effect of Na+/H+ inhibition on jejunal loop perfusion in vivo
What are the applications of Application
5-(N-Ethyl-N-isopropyl)-Amiloride is a selective Na+/H+ antiporter inhibitor
Definition
ChEBI: Ethylisopropylamiloride is a member of the class of pyrazines that is amiloride in which the amino substitutent of the pyrazine ring that is adjacent to the chloro substituent has been substituted by an ethyl group and by an isopropyl group. It has a role as an anti-arrhythmia drug, a neuroprotective agent and a sodium channel blocker. It is a member of guanidines, an aromatic amine, an organochlorine compound, a tertiary amino compound, a member of pyrazines and a monocarboxylic acid amide. It is functionally related to an amiloride.
Biochem/physiol Actions
Selective blocker of Na+/H+ antiport
storage
Store at +4°C
Properties of EIPA
Melting point: | 202-205 °C(lit.) |
Density | 1.49±0.1 g/cm3(Predicted) |
storage temp. | Keep in dark place,Sealed in dry,2-8°C |
solubility | Acetonitrile (Slightly, Heated), DMSO (Slightly), Methanol (Slightly) |
form | Off-white to yellow solid. |
pka | 8.67±0.46(Predicted) |
color | Pale Yellow to Green |
Stability: | Unstable in methanol |
CAS DataBase Reference | 1154-25-2 |
Safety information for EIPA
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for EIPA
New Products
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