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HomeProduct name listEdoxaban-d6

Edoxaban-d6

  • CAS NO.:1304701-57-2
  • Empirical Formula: C24H30ClN7O4S
  • Molecular Weight: 548.06
  • MDL number: MFCD32661438
  • Update Date: 2024-10-23 13:36:13
Edoxaban-d6 Structural

What is Edoxaban-d6?

Description

Edoxaban-d6 is intended for use as an internal standard for the quantification of edoxaban by GC- or LC-MS. Edoxaban is an orally bioavailable and potent inhibitor of factor Xa (Kis = 0.561 and 0.903 nM for free and complexed human factor Xa, respectively). It is >10,000-fold selective for factor Xa over thrombin, FVIIa/sTF, FXIa, tPA, aPC, trypsin, plasmin, and chymotrypsin. Edoxaban prolongs prothrombin, activated partial thromboplastin, and thrombin clotting times in a concentration-dependent manner ex vivo in human plasma. Oral administration of edoxaban (0.5-12.5 mg/kg) reduces thrombus formation and prolongs prothrombin time in a dose-dependent manner in rat and rabbit models of venous stasis thrombosis. It also reduces thrombus formation in a rat model of platinum wire-induced venous thrombosis. Formulations containing edoxaban have been used to prevent stroke in patients with atrial fibrillation.

The Uses of Edoxaban-d6

Edoxaban-d6 is the isotope labelled analog of Edoxaban (E555520); an anticoagulant drug which acts as a direct factor Xa inhibitor.

Properties of Edoxaban-d6

Melting point: >205°C (dec.)
storage temp.  Hygroscopic, Refrigerator, under inert atmosphere
solubility  Chloroform (Slightly), Dichloromethane (Slightly)
form  Solid
color  Pale Orange to Pale Red
Stability: Hygroscopic

Safety information for Edoxaban-d6

Computed Descriptors for Edoxaban-d6

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