EC 1.1.1.42

Synonym(s):threo-D_s-Isocitrate: NADP⁺ oxidoreductase;ICDH;IDH;IDH1;Isocitrate Dehydrogenase Cytoplasmic

CAS NO.：9028-48-2
Empirical Formula: NULL
Molecular Weight: 0
MDL number: MFCD00131420
EINECS: 232-835-3
SAFETY DATA SHEET (SDS)
Update Date: 2023-04-23 13:52:06

What is EC 1.1.1.42?

The Uses of EC 1.1.1.42

Human Isocitrate Dehydrogenase (IDH1) is useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. It may be useful as a biomarker for diagnosis and prognosis prediction of non-small cell lung cancer .

General Description

Isocitrate dehydrogenase 1 (IDH1) gene is located on human chromosome 2q33. IDH1 is present in the cytoplasm and peroxisomes. It is expressed at high levels in the mammalian liver. IDH1 consists of a C-terminal tripeptide peroxisome, that targets the signal one sequence.

Biochem/physiol Actions

Isocitrate dehydrogenase 1 (IDH1) help in the oxidative carboxylation of isocitrate to α-ketoglutarate, that results in the formation of reduced nicotinamide adenine dinucleotide phosphate (NADPH). It participates in lipid metabolism and glucose sensing. Suppressing IDH1 in pancreatic islets affects the insulin secretion, induced by glucose and leads to increase in lactate production.

Properties of EC 1.1.1.42

storage temp.	2-8°C
form	solution (clear)
color	yellow-brown

Safety information for EC 1.1.1.42

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water.