Dynorphin A (1-13)
- CAS NO.:72957-38-1
- Empirical Formula: C75H126N24O15
- Molecular Weight: 1603.95
- MDL number: MFCD00076366
- EINECS: 635-974-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-02 08:55:14
What is Dynorphin A (1-13)?
Description
Dynorphin A(1-13), a tridecapeptide of the endogenous opioid peptides, has modest effects in reducing mild opiate withdrawal in humans. Previous studies revealed that dynorphin also potentiates the analgesic effect of morphine in morphine-tolerant rats and mice. The therapeutic potential of dynorphin A(1-13) is limited due to extensive metabolism by human metabolic enzymes resulting in an in vivo half-life of less than one minute. Chemical modifications of dynorphin A(1-13), such as N-methylation of Tyr1 and amidation of the C-terminus have been shown to be effective in protecting against the proteolytic enzymes in human plasma[1].
What are the applications of Application
Dynorphin A (1-13) has been used as a test compound in the field asymmetric waveform ion mobility spectrometry coupled to mass spectrometry (FAIMS/IMS/MS).
Biochem/physiol Actions
Dynorphin A (1-13), a bioactive product of dynorphin A displays interaction with N-methyl- D-aspartate (NMDA) as well as with opioid receptors. It elevates intracellular calcium [Ca2+]i level and contributes to the loss of neurons affecting neuronal viability.
References
[1] B BRUGOS; G H. Metabolism of dynorphin A(1-13).[J]. Pharmazie, 2004.
Properties of Dynorphin A (1-13)
Density | 1.39±0.1 g/cm3(Predicted) |
RTECS | JV7436666 |
storage temp. | Inert atmosphere,Store in freezer, under -20°C |
form | Solid |
pka | 3.31±0.10(Predicted) |
color | White to off-white |
Water Solubility | Water: ≥ 60 mg/mL (37.41 mM) |
Safety information for Dynorphin A (1-13)
Computed Descriptors for Dynorphin A (1-13)
InChIKey | OVVIBUHLQIYUEU-JASZZEBFNA-N |
New Products
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