DPDPE
Synonym(s):DPDPE
- CAS NO.:88373-73-3
- Empirical Formula: C30H39N5O7S2
- Molecular Weight: 645.79
- MDL number: MFCD00076430
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-02 08:55:42
What is DPDPE?
The Uses of DPDPE
[D-Pen2,5]-Enkephalin hydrate (DPDPE) has been used to study the pharmacodynamic and pharmacokinetic capabilities of polyethylene glycol (PEG) conjugate of DPDPE in rodents. It has been used to study the tendency of opiate self-administration in male Long-Evans rats, in ventral tegmental area (VTA).
Definition
ChEBI: A heterodetic cyclic peptide that is a cyclic enkephalin analogue, having D-penicillaminyl residues located at positions 2 and 5, which form the heterocycle via a disulfide bond.
General Description
[D-Pen2,5]-Enkephalin hydrate, also called DPDPE, is a peptide and acts as a δ1-opioid receptor agonist. Opioid receptors are divided into three types called, μ, κ and δ, depending upon their ligands. These ligands are peptides and are classified as enkephalins, endorphins and dynorphins.
Biochem/physiol Actions
Antinociceptive activity mediated through the δ1 receptor while the modulatory activity is mediated through the δ2 receptor. Tritiated [D-Pen2,5]-enkephalin is used as a δ1 ligand.
Clinical Use
Nalmefene reduces alcohol consumption in adults with alcohol dependence. Morphine and hydromorphone are used in the treatment and management of severe pain. Naltrexone is used alongside behavioral therapy both for opiate addiction and for alcohol dependency. Naloxone is used to reverse narcotic depression.
storage
Store at -20°C
Properties of DPDPE
RTECS | YV9461100 |
storage temp. | −20°C |
solubility | Water:10.0(Max Conc. mg/mL);0.15(Max Conc. mM) |
form | Solid |
color | White to off-white |
Water Solubility | Soluble to 1 mg/ml in water |
Safety information for DPDPE
Computed Descriptors for DPDPE
New Products
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