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HomeProduct name list2,4-Dinitrophenylhydrazine

2,4-Dinitrophenylhydrazine

  • CAS NO.:119-26-6
  • Empirical Formula: C6H6N4O4
  • Molecular Weight: 198.14
  • MDL number: MFCD00007578
  • EINECS: 204-309-3
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-07-27 17:37:55
2,4-Dinitrophenylhydrazine Structural

What is 2,4-Dinitrophenylhydrazine?

Description

2,4-Dinitrophenylhydrazine (abbreviated 2,4-DNP for short) is the chemical compound C6H3 (NO2) 2NHNH2, and it is often used to qualitatively test for carbonyl groups associated with aldehydes and ketones. The hydrazone derivatives can also be used as evidence toward the identity of the original compound. It is relatively sensitive to shock and friction; it is a shock explosive, so care must be taken with its use. To reduce its explosive hazard, it is usually supplied wet.
2,4-Dinitrophenylhydrazine is a compound with a benzene ring, two Nitro groups, and a hydrazine (two nitrogen atoms bonded directly to each other) functional group. It is used as a Brady's reagent to test the existing of a ketone or aldehyde.

Chemical properties

white to light yellow crystal powde

The Uses of 2,4-Dinitrophenylhydrazine

2,4-Dinitrophenylhydrazine is known was Brady's reagent, a substituted hydrazine that is often used for qualitative testing of carbonyl groups associated with aldehydes and ketones.

The Uses of 2,4-Dinitrophenylhydrazine

2,4-Dinitrophenylhydrazine has been used as a reagent to detect the presence of aldehydes and ketones in protein carbonyls. It may be used as a colorimetric reagent in the quantitative estimation of prednisone.

Definition

ChEBI: 2,4-dinitrophenylhydrazine is a C-nitro compound that is phenylhydrazine substituted at the 2- and 4-positions by nitro groups. It has a role as a reagent. It is a member of phenylhydrazines and a C-nitro compound.

General Description

2,4-Dinitrophenylhydrazine (DNPH), a hydrazine derivative, is a potential mutagenic agent. Its molecular and crystal structure has been analyzed. The intra- and intermolecular hydrogen bonds in DNPH have been investigated by vibrational spectroscopic analysis. The mechanism of isothermal degradation of DNPH has been studied by differential scanning calorimetry (DSC).

Hazard

2,4-Dinitrophenylhydrazine [119-26-6] is a flammable solid, which must be kept moist and is harmful if swallowed, inhaled, or absorbed through the skin. Concentrated sulfuric acid [7664-93-9] is poisonous and corrosive. Its mist can cause severe burns to all body tissue. It may be fatal if swallowed or by skin contact. It is harmful if inhaled and may cause cancer. Ethanol [64-17-5] is flammable and should be kept from ignition sources. Eye and face protection, protective clothing, and gloves must be worn.

Purification Methods

Crystallise DNPH from butan-1-ol, dioxane, EtOH, *C6H6 or EtOAc. The hydrochloride has m 186o (dec). [Beilstein 15 IV 380.]

References

1. SOME LIMITATIONS OF 2,4-DINITROPHENYLHYDRAZINE AS A REAGENT FOR CARBONYL GROUPS. DOI:10.1021/JO01226A003
2. Linstromberg, W. W.; Baumgarten, H. E. Organic Experiments, 6th ed.; Houghton Mifflin: Boston, 2002; p 175. Shriner, R. L.; Hermann, C. K. F.; Morrill, T. C.; Curtin, D. Y.; Fuson, R. C. The Systematic Identification of Organic Compounds, 8th ed.; Wiley; Hoboken, NJ, 2004; pp 278–279.
3. An Improved Preparation of 2,4-Dinitrophenylhydrazine Reagent. DOI:10.1021/ED082P1310.2

Properties of 2,4-Dinitrophenylhydrazine

Melting point: 197-200 °C (lit.)
Boiling point: 335.43°C (rough estimate)
Density  0.843 g/mL at 20 °C
refractive index  n20/D 1.374
Flash point: 14 °C
storage temp.  2-8°C
solubility  50% sulfuric acid: 10 mg/mL, clear, colorless
form  crystals
pka 12.1(at 25℃)
color  Red
PH Range Yellow (11.0) to brown (12.5)
Water Solubility  slightly soluble
Merck  14,3283
BRN  615586
Stability: Stable when wet, but explosive when dry. May be shock sensitive when dry. Highly flammable. Incompatible with strong oxidizing agents.
Major Application Fuel cells, detecting microorganisms, antibacterial agent, treatment of acuteand chronic hepatitis, gynecopathy, cardiovascular diseases, cerebrovascular diseases
CAS DataBase Reference 119-26-6(CAS DataBase Reference)
NIST Chemistry Reference Hydrazine, (2,4-dinitrophenyl)-(119-26-6)
EPA Substance Registry System 2,4-Dinitrophenylhydrazine (119-26-6)

Safety information for 2,4-Dinitrophenylhydrazine

Signal word Danger
Pictogram(s)
ghs
Flame
Flammables
GHS02
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
Precautionary Statement Codes P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P230:Keep wetted with …
P233:Keep container tightly closed.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P370+P380+P375:in case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P501:Dispose of contents/container to..…

Computed Descriptors for 2,4-Dinitrophenylhydrazine

InChIKey HORQAOAYAYGIBM-UHFFFAOYSA-N

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