DIPROPYLENETRIAMINE

Synonym(s):BAPA;Norspermidine;Dipropylenetriamine;N-(3-Aminopropyl)-1,3-propanediamine;3,3′-Diaminodipropylamine

CAS NO.：56-18-8
Empirical Formula: C6H17N3
Molecular Weight: 131.22
MDL number: MFCD00008214
EINECS: 200-261-2
SAFETY DATA SHEET (SDS)
Update Date: 2023-05-25 18:01:02

What is DIPROPYLENETRIAMINE?

Chemical properties

colourless to yellow liquid

The Uses of DIPROPYLENETRIAMINE

A structural homologue of the natural polyamine spermidine with antitumor activity that may make it useful as a antineoplastic agent.

The Uses of DIPROPYLENETRIAMINE

Bis(3-aminopropyl)amine (BAPA) can be used:

To synthesize chitosan based hydrogels having potential biomedical applications.
For the functionalization of nanoparticles to yield terminal ?NH₂groups for further modifications.
As an internal dispersing agent for the synthesis of water-dispersible polyurethanes.
As a ligand in the preparation of [Cu(bapa)]₂[Mo(CN)₈]·7H₂O photomagnetic coordination polymer.

What are the applications of Application

Bis(3-aminopropyl)amine is a structural homologue of the natural polyamine spermidine

Definition

ChEBI: Bis(3-aminopropyl)amine is a polyazaalkane. It has a role as an algal metabolite and a plant metabolite. It is a conjugate base of a bis(3-azaniumylpropyl)azanium.

Synthesis Reference(s)

The Journal of Organic Chemistry, 58, p. 3736, 1993 DOI: 10.1021/jo00066a028
Journal of the American Chemical Society, 105, p. 5002, 1983 DOI: 10.1021/ja00353a025

General Description

A colorless liquid. Less dense than water. Flash point of 170°F. Very irritating to skin and eyes, and may be toxic by ingestion. Used to make soaps, dyes, and pharmaceuticals.

Air & Water Reactions

Water soluble.

Reactivity Profile

DIPROPYLENETRIAMINE neutralize acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides. DIPROPYLENETRIAMINE can react with oxidizing materials .

Hazard

Toxic by ingestion and inhalation; irritant.

Health Hazard

TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

Fire Hazard

Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form.

Safety Profile

Poison by skin contact. Moderately toxic by ingestion. A skin and severe eye irritant. When heated to decomposition it emits toxic fumes of NO,. An explosive

Purification Methods

Dry the amine with Na and distil it under vacuum. [Beilstein 4 IV 1278.]

Properties of DIPROPYLENETRIAMINE

Melting point:	−14 °C(lit.)
Boiling point:	151 °C50 mm Hg(lit.)
Density	0.938 g/mL at 25 °C(lit.)
refractive index	n20/D 1.481(lit.)
Flash point:	245 °F
storage temp.	2-8°C
Water Solubility	Completely miscible in water
solubility	Chloroform (Slightly), Methanol (Slightly)
pka	pK1:8.02(＋2);pK2:9.70(＋1);pK3:10.70(0) (30°C)
form	clear liquid
color	Colorless to Almost colorless
BRN	1071254
Stability:	Air and light sensitive. Combustible. Incompatible with oxidizing agents.
CAS DataBase Reference	56-18-8(CAS DataBase Reference)
EPA Substance Registry System	Norspermidine (56-18-8)

Safety information for DIPROPYLENETRIAMINE

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05 Skull and Crossbones Acute Toxicity GHS06 Health Hazard GHS08
GHS Hazard Statements	H302:Acute toxicity,oral H311:Acute toxicity,dermal H314:Skin corrosion/irritation H317:Sensitisation, Skin H330:Acute toxicity,inhalation H341:Germ cell mutagenicity H373:Specific target organ toxicity, repeated exposure
Precautionary Statement Codes	P201:Obtain special instructions before use. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P330+P331:IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.