Dinaphtho[2,3-b:2',3'-d]thiophene-5,7,12,13-tetrone
- CAS NO.:22200-69-7
- Empirical Formula: C20H8O4S
- Molecular Weight: 344.34
- Update Date: 2023-07-14 17:46:29
What is Dinaphtho[2,3-b:2',3'-d]thiophene-5,7,12,13-tetrone?
Description
Seriniquinone (22200-69-7) is a new natural product isolated from a marine bacterium of the genus Serinicoccus. Displays selective toxicity against a distinct set of cell lines (within the NCI 60 panel) predominantly melanoma. Upon cellular treatment, seriniquinone was found to localize in the endoplasmic reticulum. Within 3 hours cells underwent autophagy followed by death via a caspase-9 apoptotic pathway. The target of seriniquinone was identified as the small protein, dermcidin, as determined using an immunoaffinity approach.1
The Uses of Dinaphtho[2,3-b:2',3'-d]thiophene-5,7,12,13-tetrone
Seriniquinone is a marine natural product, that displays potent cytotoxicity and selectivity against melanoma cancer cells.
References
1) Trzoss?et al. (2014),?Seriniquinone, a selective anticancer agent, induces cell death by autophagocytosis, targeting the cancer-protective protein dermcidin; Proc. Natl. Acad. Sci. USA,?111?14687
Properties of Dinaphtho[2,3-b:2',3'-d]thiophene-5,7,12,13-tetrone
Melting point: | 288 °C |
Boiling point: | 612.3±54.0 °C(Predicted) |
Density | 1.578±0.06 g/cm3(Predicted) |
storage temp. | -20°C |
solubility | Soluble in DMSO (up to 15 mg/ml with warming) or in DMF (up to 15 mg/ml) |
form | solid |
color | Orange |
Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20°C for up to 3 months. |
Safety information for Dinaphtho[2,3-b:2',3'-d]thiophene-5,7,12,13-tetrone
Computed Descriptors for Dinaphtho[2,3-b:2',3'-d]thiophene-5,7,12,13-tetrone
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