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HomeProduct name listDifenacoum

Difenacoum

Synonym(s):3-(3-Biphenyl-4-yl-1,2,3,4-tetrahydro-1-naphthyl)-4-hydroxycoumarin;3-(3-Biphenyl-4-yl-1,2,3,4-tetrahydro-naphthalen-1-yl)-4-hydroxychromen-2-one

  • CAS NO.:56073-07-5
  • Empirical Formula: C31H24O3
  • Molecular Weight: 444.52
  • MDL number: MFCD01632770
  • EINECS: 259-978-4
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-05-15 10:43:13
Difenacoum Structural

What is Difenacoum?

Description

Difenacoum, is also called 3-(3-biphenyl-4-yl-1,2,3,4- tetrahydro-1-naphthyl)-4-hydroxycoumarin, consists of colorless crystals which are insoluble in water, moderately to readily soluble in acetone, chloroform, ethyl acetate, benzene.Difenacoum is synthesized by the condensation of 4-hydroxycoumarin and 3-biphenyl-4-yl-1,2,3,4-tetrahydro-1-naphthol (49).

The Uses of Difenacoum

Difenacoum is a 4-hydroxycouramin derivative. Difenacoum is a second generation anticoagulant rodenticide used against rodent pests such as rats and mice.

The Uses of Difenacoum

Pesticide.

Definition

ChEBI: Difenacoum is a ring assembly, a member of benzenes and a member of naphthalenes.

Agricultural Uses

Rodenticide: Difenacoum is an anticoagulant that is effective against rats and mice, including warfarin-resistant strains. It is used in agriculture and urban rodent control as ready-to-use baits.

Trade name

COMPO®; MATRAK®; NEOSOREXA® PELLETS; NEOSOREXA PP580®; RASTOP®; RATAK®; RATRICK®; SILO; SOREXA GEL; STORM

Safety Profile

A poison by ingestion and skincontact. When heated to decomposition it emits acridsmoke and irritating vapors.

Toxicity evaluation

Appearing in 1974, difenacoum was the first of the new generation of anticoagulants to be commercialized for the control of rodents resistant to warfarin and related compounds (42). LD50 values (acute oral) for warfarinsusceptible rodent strains are about a factor of 2 lower than for warfarin-resistant strains. There is also a degree of specificity. The compound is generally less toxic to nontarget animals than to targets. A wide range of bait types containing 0.005% difenacoum is available, including meals, broken and whole grains, pellets, and wax blocks. A 0.1% contact dust is no longer widely used. Resistance to difenacoum was detected among a population of Norway rats in the United Kingdom in 1978 (50). This remains a problem of local importance but relatively low resistance factors indicate that other behavioral factors also play a significant role (51). Difenacoum resistance has also been recorded in other European countries (39).

Properties of Difenacoum

Melting point: 215-217°
Boiling point: 514.5°C (rough estimate)
Density  1.0800 (rough estimate)
refractive index  1.5500 (estimate)
solubility  Chloroform (Slightly), Methanol (Slightly)
pka 4.50±1.00(Predicted)
form  neat
BRN  8360065
CAS DataBase Reference 56073-07-5(CAS DataBase Reference)
EPA Substance Registry System Difenacoum (56073-07-5)

Safety information for Difenacoum

Signal word Danger
Pictogram(s)
ghs
Skull and Crossbones
Acute Toxicity
GHS06
ghs
Health Hazard
GHS08
ghs
Environment
GHS09
GHS Hazard Statements H372:Specific target organ toxicity, repeated exposure
H410:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes P202:Do not handle until all safety precautions have been read and understood.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P273:Avoid release to the environment.
P280:Wear protective gloves/protective clothing/eye protection/face protection.

Computed Descriptors for Difenacoum

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