Diethyl acetamidomalonate
Synonym(s):Acetamidomalonic acid diethyl ester
- CAS NO.：1068-90-2
- Empirical Formula: C9H15NO5
- Molecular Weight: 217.22
- MDL number: MFCD00009146
- EINECS: 213-952-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-12-18 14:08:52
What is Diethyl acetamidomalonate?
Chemical properties
white to light yellow crystalline powder
The Uses of Diethyl acetamidomalonate
Diethyl 2-Acetamidomalonate, is a versatile building block used for the synthesis of various pharmaceutical and biologically active compounds. It is an intermediate for the preparation of Novobiocin analogues as potential heat shock protein 90 inhibitors. It is also used as a important intermediates in syntheses of vitamins B1 and B6, barbiturates, non-steroidal anti-inflammatory agents, other numerous pharmaceuticals.
Safety Profile
An eye irritant. When heated todecomposition it emits toxic fumes of NOx.
Purification Methods
Crystallise the ester from *benzene/pet ether. [Beilstein 4 III 2993.]
Properties of Diethyl acetamidomalonate
| Melting point: | 95-98 °C (lit.) |
| Boiling point: | 185 °C/20 mmHg (lit.) |
| Density | 1.2850 (rough estimate) |
| refractive index | 1.4640 (estimate) |
| Flash point: | 185°C/20mm |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| pka | 11.93±0.59(Predicted) |
| form | Crystalline Powder |
| color | White to light yellow |
| Water Solubility | Soluble in chloroform and methanol. Slightly soluble in water. |
| BRN | 783883 |
| CAS DataBase Reference | 1068-90-2(CAS DataBase Reference) |
| NIST Chemistry Reference | Propanedioic acid, (acetylamino)-, diethyl ester(1068-90-2) |
| EPA Substance Registry System | Propanedioic acid, 2-(acetylamino)-, 1,3-diethyl ester (1068-90-2) |
Safety information for Diethyl acetamidomalonate
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05 |
| GHS Hazard Statements |
H290:Corrosive to Metals H314:Skin corrosion/irritation |
| Precautionary Statement Codes |
P234:Keep only in original container. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P363:Wash contaminated clothing before reuse. P390:Absorb spillage to prevent material damage. P301+P330+P331:IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P405:Store locked up. P406:Store in corrosive resistant/… container with a resistant inner liner. |
Computed Descriptors for Diethyl acetamidomalonate
| InChIKey | ISOLMABRZPQKOV-UHFFFAOYSA-N |
Diethyl acetamidomalonate manufacturer
ALTRAKEM PHARMA LIFE SCIENCES PRIVATE LIMITED
2Y
Phone:+91-9966658228
Whatsapp: +91- 9966658228
product: 1068-90-2 Diethyl acetamidomalonate 99%
JSK Chemicals
2Y
Phone:+919879767970
Whatsapp: +91 9879767970
product: 1068-90-2 Diethyl acetamidomalonate, 98% 99%
Synaptics Labs Private Limited
1Y
Phone:+918341963666
Whatsapp: +91 8341963666
product: 1068-90-2 98%
Dr. Silviu Pharmachem Pvt., Ltd.
1Y
Phone:+91-8390608382
Whatsapp: +91 8390608382
product: Diethyl acetamidomalonate 98%
Glyra Health Care Pvt Ltd
Phone:+91-9727720767
Whatsapp: +91-9727720767
product: Diethyl acetamidomalonate 1068-90-2 99%
Scinva Chemicals and Pharmaceuticals Pvt Ltd
1Y
Phone:+917406196725
Whatsapp: +91-7406196725
product: 1068-90-2 Diethyl acetamidomalonate 98%
Anand Agencies
Maharashtra
Phone:91-9075014125
Whatsapp: 91-9075014125
product: Diethyl acetamidomalonate
New Products
(S)-3-Aminobutanenitrile hydrochloride 4-Methylphenylacetic acid N-Boc-D-alaninol N-BOC-D/L-ALANINOL Tert-butyl bis(2-chloroethyl)carbamate 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin- 2(1H)-one Furan-2,5-Dicarboxylic Acid Tropic acid 1-Bromo-3,5-Di-Tert-Butylbenzene S-2-CHLORO PROPIONIC ACID ETHYL ISOCYANOACETATE 2-Bromo-1,3-Bis(Dimethylamino)Trimethinium Hexafluorophosphate 4-IODO BENZOIC ACID 3-NITRO-2-METHYL ANILINE 1-(2,4-DICHLOROPHENYL) ETHANAMINE (2-Hydroxyphenyl)acetonitrile 4-Bromopyrazole 2-(Cyanocyclohexyl)acetic acid 4-methoxy-3,5-dinitropyridine 1-(4-(aminomethyl)benzyl)urea hydrochloride 2-aminopropyl benzoate hydrochloride diethyl 2-(2-((tertbutoxycarbonyl)amino) ethyl)malonate tert-butyl 4- (ureidomethyl)benzylcarbamate Ethyl-2-chloro((4-methoxyphenyl)hydrazono)acetateRelated products of tetrahydrofuran
You may like
-
Diethyl 2-acetamidomalonate 98%View Details
1068-90-2 -
2-acetylaminomalonic acid diethyl ester 1068-90-2 98%View Details
1068-90-2 -
Diethyl acetamidomalonate CAS 1068-90-2View Details
1068-90-2 -
1068-90-2 95-99%View Details
1068-90-2 -
Diethyl Acetamidomalonate CAS 1068-90-2View Details
1068-90-2 -
1068-90-2 Diethyl acetamidomalonate, 98% 99%View Details
1068-90-2 -
Diethyl acetamidomalonate 99% CAS 1068-90-2View Details
1068-90-2 -
Diethyl acetamidomalonate CAS 1068-90-2View Details
1068-90-2
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.