DICLOFENAC-D4
- CAS NO.:153466-65-0
- Empirical Formula: C14H11Cl2NO2
- Molecular Weight: 296.15
- MDL number: MFCD06658788
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-28 23:16:16
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What is DICLOFENAC-D4?
Description
Diclofenac-d4 is intended for use as an internal standard for the quantification of diclofenac (Item Nos. 70680 | 22983) by GC- or LC-MS. Diclofenac is a non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor (IC50s = 0.9-2.7 and 1.5-20 μM, for human COX-1 and COX-2, respectively). It is also an active metabolite of diclofenac methyl ester and diclofenac amide . Diclofenac inhibits release of arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) induced by A23187 in isolated rat peritoneal neutrophils and macrophages (IC50s = 60 and 10 μM, respectively). Transdermal administration of diclofenac inhibits carrageenan-induced paw edema in rats. Formulations containing diclofenac have been used in the treatment of pain associated with osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis.
Chemical properties
Off-White Crystalline Solid
The Uses of DICLOFENAC-D4
Labeled Diclofenac, a nonsteroidal anti-inflammatory compound and cyclooxygenase (COX) inhibitor. 92% overall isotopic purity. A representative lot was 75% d4, 23% d3 and 2 % d2
The Uses of DICLOFENAC-D4
Labelled Diclofenac, a nonsteroidal anti-inflammatory compound and cyclooxygenase (COX) inhibitor.
The Uses of DICLOFENAC-D4
Labelled Diclofenac is a known nonsteroidal anti-inflammatory compound and cyclooxygenase (COX) inhibitor.
What are the applications of Application
Diclofenac-d4 is a nonsteroidal anti-inflammatory compound and a COX inhibitor
Properties of DICLOFENAC-D4
Melting point: | 157-159°C |
storage temp. | -20°C Freezer |
solubility | DMSO: 35 mg/ml,Ethanol: 35 mg/ml,PBS (pH 7.2): 6 mg/ml |
form | A solid |
color | White to off-white |
Water Solubility | Water: 50 mg/ml |
CAS DataBase Reference | 153466-65-0 |
Safety information for DICLOFENAC-D4
Computed Descriptors for DICLOFENAC-D4
New Products
1-Amino-1-cyclohexanecarboxylic acid 6-Bromo-3-iodo-1-methyl-1H-indazole 3-(2,4-Dimethoxybenzyl)dihydropyrimidine-2,4(1H,3H)-dione S-Methylisothiosemicarbazide hydroiodide ELECTROLYTIC IRON POWDER 1-Aminocyclobutanecarboxylic acid 1-(2-Ethoxyethyl)-2-(piperidin-4-yl)-1H-benzo[d]imidazole hydrochloride tert-butyl 4-(1H-benzo[d]iMidazol-2-yl)piperidine-1-carboxylate Decanonitrile N,N'-diallyl-1,3-diaminopropanedihydrochloride N-(3-Nitrophenyl)cyclopropanecarboxamide (2-amino-2-phenylethyl)(methyl)amine Methyl-2-acetamidobenzoate methyl 6-chloro-2-(chloromethyl)nicotinate 2-methoxy-4-methyl-5-nitro pyridine 2-iodo-5-bromo pyridine 2-amino-4-methyl-5-nitro pyridine 4-cyano benzaldehyde 2-hydroxy-5-bromo pyridine 5-Fluoro-2-Oxindole 3,5-Dichloro-2,6-Dimethyl-1h-Pyridin-4-One (9H-fluoren-9-yl)methyl carbonochloridate 2-methyl-5-nitroaniline (S)-1-(tert-butoxycarbonyl)-4-oxopyrrolidine-2-carboxylic acidRelated products of tetrahydrofuran
![DICLOFENAC POTASSIUM /POTASSIUM [2-[(2,6-DICHLOROPHENYL)AMINO]PHENYL]ACETATE](https://img.chemicalbook.in/CAS/GIF/15307-81-0.gif)
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