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HomeProduct name listDICLOFENAC-D4

DICLOFENAC-D4

DICLOFENAC-D4 Structural

What is DICLOFENAC-D4?

Description

Diclofenac-d4 is intended for use as an internal standard for the quantification of diclofenac (Item Nos. 70680 | 22983) by GC- or LC-MS. Diclofenac is a non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor (IC50s = 0.9-2.7 and 1.5-20 μM, for human COX-1 and COX-2, respectively). It is also an active metabolite of diclofenac methyl ester and diclofenac amide . Diclofenac inhibits release of arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) induced by A23187 in isolated rat peritoneal neutrophils and macrophages (IC50s = 60 and 10 μM, respectively). Transdermal administration of diclofenac inhibits carrageenan-induced paw edema in rats. Formulations containing diclofenac have been used in the treatment of pain associated with osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis.

Chemical properties

Off-White Crystalline Solid

The Uses of DICLOFENAC-D4

Labeled Diclofenac, a nonsteroidal anti-inflammatory compound and cyclooxygenase (COX) inhibitor. 92% overall isotopic purity. A representative lot was 75% d4, 23% d3 and 2 % d2

The Uses of DICLOFENAC-D4

Labelled Diclofenac, a nonsteroidal anti-inflammatory compound and cyclooxygenase (COX) inhibitor.

The Uses of DICLOFENAC-D4

Labelled Diclofenac is a known nonsteroidal anti-inflammatory compound and cyclooxygenase (COX) inhibitor.

What are the applications of Application

Diclofenac-d4 is a nonsteroidal anti-inflammatory compound and a COX inhibitor

Properties of DICLOFENAC-D4

Melting point: 157-159°C
storage temp.  -20°C Freezer
solubility  DMSO: 35 mg/ml,Ethanol: 35 mg/ml,PBS (pH 7.2): 6 mg/ml
form  A solid
color  White to off-white
Water Solubility  Water: 50 mg/ml
CAS DataBase Reference 153466-65-0

Safety information for DICLOFENAC-D4

Computed Descriptors for DICLOFENAC-D4

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