DICHLORISONE ACETATE
Synonym(s):9α,11β-Dichloro-17α,21-dihydroxypregna-1,4-diene-3,20-dione 21-acetate
- CAS NO.:79-61-8
- Empirical Formula: C23H28Cl2O5
- Molecular Weight: 455.37
- MDL number: MFCD00133265
- EINECS: 201-213-3
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 20:33:22
What is DICHLORISONE ACETATE?
Originator
Diloderm ,Schering,US,1960
The Uses of DICHLORISONE ACETATE
antipruretic
Definition
ChEBI: Dichlorisone is a corticosteroid hormone.
Manufacturing Process
A solution of 1.0 g of 1,4,9(11)-pregnatriene-17α,21-diol-3,20-dione-21-
acetate and 5.0 g of lithium chloride in 40 ml of glacial acetic acid is treated
with 0.410 g of N-chlorosuccinimide, followed by 0.104 g of anhydrous
hydrogen chloride dissolved in 2.5 ml of tetrahydrofuran. The reaction mixture
is stirred for 2 hours and poured into ice water. The crude product is filtered
and washed with water to give 1.12 g of solid material, which is recrystallized
from acetone-hexane to give substantially pure 9α,11β-dichloro-1,4-
pregnadiene-17α,21-diol-3,20-dione-21-acetate; MP 246°C to 253°C (dec.).
brand name
Diloderm (Schering).
Therapeutic Function
Antipruritic, Antihistaminic, Appetite stimulant
Properties of DICHLORISONE ACETATE
Melting point: | 246-253 °C (decomp) |
Boiling point: | 596.2±50.0 °C(Predicted) |
alpha | D25 +162° (dioxane) |
Density | 1.34±0.1 g/cm3(Predicted) |
storage temp. | Store at -20°C |
solubility | DMSO: 4.35 mg/mL (9.55 mM); Water: < 0.1 mg/mL (insoluble) |
pka | 11.94±0.70(Predicted) |
form | Solid |
color | White to off-white |
Safety information for DICHLORISONE ACETATE
Computed Descriptors for DICHLORISONE ACETATE
New Products
(S)-3-Aminobutanenitrile hydrochloride 4-Methylphenylacetic acid N-Boc-D-alaninol N-BOC-D/L-ALANINOL Tert-butyl bis(2-chloroethyl)carbamate 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin- 2(1H)-one Furan-2,5-Dicarboxylic Acid Tropic acid 1-Bromo-3,5-Di-Tert-Butylbenzene S-2-CHLORO PROPIONIC ACID ETHYL ISOCYANOACETATE 2-Bromo-1,3-Bis(Dimethylamino)Trimethinium Hexafluorophosphate 4-IODO BENZOIC ACID 3-NITRO-2-METHYL ANILINE 1-(2,4-DICHLOROPHENYL) ETHANAMINE (2-Hydroxyphenyl)acetonitrile 4-Bromopyrazole 2-(Cyanocyclohexyl)acetic acid 4-methoxy-3,5-dinitropyridine 1-(4-(aminomethyl)benzyl)urea hydrochloride 2-aminopropyl benzoate hydrochloride diethyl 2-(2-((tertbutoxycarbonyl)amino) ethyl)malonate tert-butyl 4- (ureidomethyl)benzylcarbamate Ethyl-2-chloro((4-methoxyphenyl)hydrazono)acetateRelated products of tetrahydrofuran
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