DICHLORISONE ACETATE

Synonym(s):9α,11β-Dichloro-17α,21-dihydroxypregna-1,4-diene-3,20-dione 21-acetate

CAS NO.：79-61-8
Empirical Formula: C23H28Cl2O5
Molecular Weight: 455.37
MDL number: MFCD00133265
EINECS: 201-213-3
SAFETY DATA SHEET (SDS)
Update Date: 2024-07-02 08:54:58

What is DICHLORISONE ACETATE?

Originator

Diloderm ,Schering,US,1960

The Uses of DICHLORISONE ACETATE

antipruretic

Definition

ChEBI: Dichlorisone is a corticosteroid hormone.

Manufacturing Process

A solution of 1.0 g of 1,4,9(11)-pregnatriene-17α,21-diol-3,20-dione-21- acetate and 5.0 g of lithium chloride in 40 ml of glacial acetic acid is treated
with 0.410 g of N-chlorosuccinimide, followed by 0.104 g of anhydrous hydrogen chloride dissolved in 2.5 ml of tetrahydrofuran. The reaction mixture is stirred for 2 hours and poured into ice water. The crude product is filtered and washed with water to give 1.12 g of solid material, which is recrystallized from acetone-hexane to give substantially pure 9α,11β-dichloro-1,4- pregnadiene-17α,21-diol-3,20-dione-21-acetate; MP 246°C to 253°C (dec.).

brand name

Diloderm (Schering).

Therapeutic Function

Antipruritic, Antihistaminic, Appetite stimulant

Properties of DICHLORISONE ACETATE

Melting point:	246-253 °C (decomp)
Boiling point:	596.2±50.0 °C(Predicted)
alpha	D25 +162° (dioxane)
Density	1.34±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO: 4.35 mg/mL (9.55 mM); Water: < 0.1 mg/mL (insoluble)
pka	11.94±0.70(Predicted)
form	Solid
color	White to off-white