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HomeProduct name list2-Hydroxy Atorvastatin Calcium Salt

2-Hydroxy Atorvastatin Calcium Salt

2-Hydroxy Atorvastatin Calcium Salt Structural

What is 2-Hydroxy Atorvastatin Calcium Salt?

Chemical properties

White to Pale Yellow Solid

The Uses of 2-Hydroxy Atorvastatin Calcium Salt

di(2-Hydroxy Atorvastatin) Calcium Salt is a metabolite of Atorvastatin Calcium Salt (A791750), a selective, competitive HMG-CoA reductase inhibitor. Atorvastatin is the only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterolemia.

What are the applications of Application

2-Hydroxy Atorvastatin Calcium Salt is a metabolite of Atorvastatin Calcium Salt

Biological Activity

2-Hydroxy atorvastatin calcium salt is a hydroxy metabolite of Atorvastatin calcium salt. Atorvastatin is a potent HMG-CoA reductase inhibitor with an IC50 value of 8 nM. It inhibits lipid hydroperoxide formation and copper sulfate-induced thiobarbituric acid reactive substances (TBARS) formation in 1,2-dilinoleoyl-sn-glycero-3-PC (DLPC) vesicles and human LDL, respectively, in a concentration-dependent manner. 2-Hydroxy Atorvastatin reduces cell death induced by oxygen-glucose deprivation (OGD) in primary rat cortical neurons and increases phosphorylation of cAMP-response-element-binding protein (CREB) in GABAergic neurons when used at a concentration of 600 nM following OGD.

Properties of 2-Hydroxy Atorvastatin Calcium Salt

Melting point: >166°C (dec.)
storage temp.  Hygroscopic, Refrigerator, under inert atmosphere
solubility  DMSO (Slightly), Methanol (Slightly)
form  Solid
color  White to Yellow
Stability: Hygroscopic

Safety information for 2-Hydroxy Atorvastatin Calcium Salt

Computed Descriptors for 2-Hydroxy Atorvastatin Calcium Salt

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