2-Hydroxy Atorvastatin Calcium Salt
- CAS NO.:265989-46-6
- Empirical Formula: C33H37CaFN2O6
- Molecular Weight: 616.74
- MDL number: MFCD08063637
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-28 23:16:16
What is 2-Hydroxy Atorvastatin Calcium Salt?
Chemical properties
White to Pale Yellow Solid
The Uses of 2-Hydroxy Atorvastatin Calcium Salt
di(2-Hydroxy Atorvastatin) Calcium Salt is a metabolite of Atorvastatin Calcium Salt (A791750), a selective, competitive HMG-CoA reductase inhibitor. Atorvastatin is the only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterolemia.
What are the applications of Application
2-Hydroxy Atorvastatin Calcium Salt is a metabolite of Atorvastatin Calcium Salt
Biological Activity
2-Hydroxy atorvastatin calcium salt is a hydroxy metabolite of Atorvastatin calcium salt. Atorvastatin is a potent HMG-CoA reductase inhibitor with an IC50 value of 8 nM. It inhibits lipid hydroperoxide formation and copper sulfate-induced thiobarbituric acid reactive substances (TBARS) formation in 1,2-dilinoleoyl-sn-glycero-3-PC (DLPC) vesicles and human LDL, respectively, in a concentration-dependent manner. 2-Hydroxy Atorvastatin reduces cell death induced by oxygen-glucose deprivation (OGD) in primary rat cortical neurons and increases phosphorylation of cAMP-response-element-binding protein (CREB) in GABAergic neurons when used at a concentration of 600 nM following OGD.
Properties of 2-Hydroxy Atorvastatin Calcium Salt
Melting point: | >166°C (dec.) |
storage temp. | Hygroscopic, Refrigerator, under inert atmosphere |
solubility | DMSO (Slightly), Methanol (Slightly) |
form | Solid |
color | White to Yellow |
Stability: | Hygroscopic |
Safety information for 2-Hydroxy Atorvastatin Calcium Salt
Computed Descriptors for 2-Hydroxy Atorvastatin Calcium Salt
Abamectin manufacturer
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