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HomeProduct name listDANSYL ETHYLENEDIAMINE

DANSYL ETHYLENEDIAMINE

Synonym(s):N-(2-Aminoethyl)-5-dimethylamino-1-naphthalenesulfonamide;N-(2-Aminoethyl)dansylamide;DNSEDA;NSC 666752

  • CAS NO.:35060-08-3
  • Empirical Formula: C14H19N3O2S
  • Molecular Weight: 293.38
  • MDL number: MFCD00467523
  • EINECS: 233-305-4
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-08-11 15:28:25
DANSYL ETHYLENEDIAMINE Structural

What is DANSYL ETHYLENEDIAMINE?

Description

Dansyl ethylenediamine is a lipophilic fluorophore that can be coupled to coarboxylic acids of proteins and other water-soluble polymers. The primary aliphatic amine of dansyl ethylenediamine can be reversibly coupled to aldehydes and ketones to form a Schiff base, which can be reduced to a generate stable amine derivative by sodium borohydride (NaBH4) or sodium cyanoborohydride (NaCNH3). Spectral data: λex=335nm, λem=525nm in methanol. Dansyl ethylenediamine has also shown to inhibit human renal dipeptidase (hrDP) irreversibly in a time-dependent manner.

Chemical properties

Yellow to orange powder.

The Uses of DANSYL ETHYLENEDIAMINE

A fluorescent reagent

The Uses of DANSYL ETHYLENEDIAMINE

A fluorescent reagent.

References

[1] YUKI INOUE. Fluorescent molecularly imprinted polymer thin films for specific protein detection prepared with dansyl ethylenediamine-conjugated O-acryloyl l-hydroxyproline[J]. Biosensors and Bioelectronics, 2013. DOI:10.1016/j.bios.2013.03.005.
[2] ADACHIH. Importance of Glu-125 in the catalytic activity of human renal dipeptidase.[J]. Biochimica et biophysica acta, 1993. DOI:10.1016/0167-4838(93)90276-w.
[3] MALLAMPATI S, AERSCHOT A V, HOOGMARTENS J, et al. Analysis of dideoxyadenosine triphosphate by CE with fluorescence detection. I. Derivatization through the phosphate group[J]. ELECTROPHORESIS, 2007, 28. DOI:10.1002/elps.200700234.
[4] DUDLEY R W, SLOTTERBECK B D, MCINERNEY M F, et al. Fatty acylation enhances cellular localization of dansylated phenylalanines[J]. Molecular and Cellular Biochemistry, 2010, 346: 81-87. DOI:10.1007/s11010-010-0593-4.

Properties of DANSYL ETHYLENEDIAMINE

Melting point: 145-146°C
Boiling point: 470.2±55.0 °C(Predicted)
Density  1.262±0.06 g/cm3(Predicted)
storage temp.  -20°C Freezer
solubility  methanol: soluble1mg/mL, clear, slightly yellow to deep yellow
form  Solid
pka 11.30±0.50(Predicted)
color  Light Yellow
BRN  2817535

Safety information for DANSYL ETHYLENEDIAMINE

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for DANSYL ETHYLENEDIAMINE

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