D-ERYTHRONOLACTONE
Synonym(s):(3R-cis) (−)-Dihydro-3,4-dihydroxy-2(3H)-furanone;D -Erythronic acid γ-lactone;D -Erythronolactone
- CAS NO.：15667-21-7
- Empirical Formula: C4H6O4
- Molecular Weight: 118.09
- MDL number: MFCD00077763
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-04 17:34:34
What is D-ERYTHRONOLACTONE?
Chemical properties
D-ERYTHRONOLACTONE is white to light yellow crystal powde
The Uses of D-ERYTHRONOLACTONE
D-ERYTHRONOLACTONE is a chiral synthon used for the synthesis of certain natural products such as the leukotrienes
The Uses of D-ERYTHRONOLACTONE
D-erythrono-1,4-lactone is a potential substrates of dihydroxy acid dehydratase.
The Uses of D-ERYTHRONOLACTONE
A chiral synthon used for the synthesis of certain natural products such as the leukotrienes.
What are the applications of Application
D-Erythronolactone is a chiral synthon used to create analogs of certain natural products
Definition
ChEBI: Erythrono-1,4-lactone is a butan-4-olide that is dihydrofuran-2-one substituted at C-3 and C-4 by hydroxy groups (the 3R,4R-diastereomer). It is a butan-4-olide and a diol.
Purification Methods
Recrystallise it from EtOAc (20 parts) or isoPrOH (3 parts). [Baker & MacDonald J Am Chem Soc 82 230 1960, Glattfeld & Forbrich J Am Chem Soc 56 1209 1934, Weidenhagen & Wegner Chem Ber 72 2010 1939, Musich & Rapoport J Am Chem Soc 100 4865 1978, Beilstein 18/2 V 457.]
Properties of D-ERYTHRONOLACTONE
| Melting point: | 100-102 °C(lit.) |
| Boiling point: | 140.59°C (rough estimate) |
| Density | 1.0887 (rough estimate) |
| refractive index | -71 ° (C=1, H2O) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 12.34±0.40(Predicted) |
| color | White to Off-White |
| optical activity | [α]20/D 71°, c = 1 in H2O |
| BRN | 81073 |
| CAS DataBase Reference | 15667-21-7(CAS DataBase Reference) |
Safety information for D-ERYTHRONOLACTONE
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. |
Computed Descriptors for D-ERYTHRONOLACTONE
New Products
6-Bromo 2-Iodo Indole Pyridine 2,4,6-Tricarboxaldehyde Fosfomycin EP impurity D Rimegepant Impurity 3 Ivermectin EP Impurity B Tubulysin E Tubulysin H (R)-tert-butyl (4-methyl-1-oxopentan-3-yl)carbamate (2S,4R)-4-amino-2-methyl-5-phenylpentanoic acid hydrochloride Diethyl Aluminium Cyanide (1.0 M in Toluene) 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile Fuel shell (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol Calcium Sodium Phosphosilicate IH 4-Bromo-N,N-bis(4-iodophenyl)aniline Methyl 4-amino-3-(piperidin-1-yl)benzoate 2-Chloro-3-(chloromethyl)pyridine Diethyl 2,5-di(furan-2-yl)terephthalate 2-(3,5-Di-tert-butylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 3,6-Bis(4-iodophenyl)-2,5-dihydropyrrolo[3,4-c]pyrrole-1,4-dione 5-Amino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile N-Boc-(S)-2-amino-3-benzyloxy-1-propanolRelated products of tetrahydrofuran
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