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HomeProduct name listCYCLOSPORIN D

CYCLOSPORIN D

Synonym(s):1-(3-Chlorophenyl)piperazine-D8 hydrochloride solution

  • CAS NO.:63775-96-2
  • Empirical Formula: C63H113N11O12
  • Molecular Weight: 1216.64
  • MDL number: MFCD11111526
  • EINECS: 806-434-4
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-06-30 15:45:59
CYCLOSPORIN D Structural

What is CYCLOSPORIN D?

Chemical properties

Colorless Crystalline Solid

The Uses of CYCLOSPORIN D

Cyclosporin D is a minor analogue of the cyclosporin family which is only weakly immunologically active. Cyclosporin D is a potent inhibitor of tumour-promoting phorbol esters on mouse skin in vivo, and a potent inhibitor of calcium/calmodulin-dependent EF-2 phosphorylation in vitro.

The Uses of CYCLOSPORIN D

A group of nonpolar cyclic oligopeptides with immunosupppressant activity.

What are the applications of Application

Cyclosporin D is a potent inhibitor of tumor promoting phorbol ester TPA/PMA

Biological Activity

cyclosporin d is an immunosuppressive agent [1].cyclosporin d (csd) is an analogue of cyclosporine a with weak immunosuppressive activity. cyclosporin d has been used as an internal standard for the quantification of cyclosporin a. in human multidrug-resistant ovarian cancer cells, cyclosporin d significantly overcame adriamycin resistance [2]. in lymphocyte, csd weakly inhibited pha-, pwm-, and pma + ca2+-induced cell proliferation [3].in mice, csd inhibited edema in mouse ear and alkaline phosphatase activity in mouse skin induced by tpa by 98% and 88%, respectively. in cytosol of mouse pancreas, csd inhibited the ca2+/calmodulin-dependent phosphorylation of the elongation factor 2 (ef-2) and the tpa-induced increase of ef-2 [1]. cyclosporin d was effective in inhibiting p. falciparum parasite in vitro and p. berghei malaria parasite development in vivo when administered orally [4].

storage

+4°C

References

[1]. gschwendt m, kittstein w, marks f. the weak immunosuppressant cyclosporine d as well as the immunologically inactive cyclosporine h are potent inhibitors in vivo of phorbol ester tpa-induced biological effects in mouse skin and of ca2+/calmodulin dependent ef-2 phosphorylation in vitro. biochem biophys res commun, 1988, 150(2): 545-551.
[2]. mizuno k, furuhashi y, misawa t, et al. modulation of multidrug resistance by immunosuppressive agents: cyclosporin analogues, fk506 and mizoribine. anticancer res, 1992, 12(1): 21-25.
[3]. sadeg n, pham-huy c, rucay p, et al. in vitro and in vivo comparative studies on immunosuppressive properties of cyclosporines a, c, d and metabolites m1, m17 and m21. immunopharmacol immunotoxicol, 1993, 15(2-3): 163-177.
[4]. uadia po1, ezeamuzie ic, ladan mj, et al. antimalarial activity of cyclosporins a, c and d. afr j med med sci, 1994, 23(1): 47-51.

Properties of CYCLOSPORIN D

Melting point: 148-1510C
Boiling point: 1294.7±65.0 °C(Predicted)
alpha  D20 -245° (c = 0.52 in CHCl3); D20 -211° (c = 0.51 in methanol)
Density  1.015±0.06 g/cm3(Predicted)
Flash point: 9 °C
storage temp.  -20°C Freezer
solubility  Chloroform (Sparingly), Ethyl Aceatate (Slightly), Methanol (Slightly)
form  Colorless to off-white crystalline solid.
pka 13.22±0.70(Predicted)
color  White to Off-White

Safety information for CYCLOSPORIN D

Signal word Danger
Pictogram(s)
ghs
Flame
Flammables
GHS02
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H225:Flammable liquids
H319:Serious eye damage/eye irritation
Precautionary Statement Codes P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for CYCLOSPORIN D

InChIKey YJDYDFNKCBANTM-QCWCSKBGSA-N

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