CYCLOPENTYL PHENYL KETONE
- CAS NO.:5422-88-8
- Empirical Formula: C12H14O
- Molecular Weight: 174.24
- MDL number: MFCD00001378
- EINECS: 226-548-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-05 08:26:49
What is CYCLOPENTYL PHENYL KETONE?
Description
Phenyl cyclopentyl ketone (Item No. 31036) is an analytical reference standard categorized as a precursor in the synthesis of ketamine (Item Nos. 19389 | 11630). This product is intended for research and forensic applications.
The Uses of CYCLOPENTYL PHENYL KETONE
Cyclopentyl Phenyl Ketone is used in the preparation of ortho-arylated compounds and phenanthrones by palladium-catalyzed chelation-assisted C-H activation of Cyclopentyl Phenyl Ketone.
The Uses of CYCLOPENTYL PHENYL KETONE
Phenylcyclopentyl ketone is the key intermediate of synthetic hydrochloric acid amyl ethyl quin ether.
Synthesis
In 100ml round-bottomed flask, by 2-cyclopenta ethyl benzoylacetate (10.6g, 43.05mmol, 1.0eq), NaOH (2.6g, 64.5mmol) and Na2CO3(4.5g, 43mmol), is suspended in 50.0mLH2In O, it is warmed up to 80 DEG C and reacts 3 hours, obtain product phenylcyclopentyl ketone.Purify: reactant liquor is cooled to room temperature, extract 3 times with ethyl acetate 20mL;Organic phase saturated sodium-chloride washs, and merges organic phase and uses anhydrous MgSO4Being dried, then remove solvent under reduced pressure, obtain thick product, column chromatography purifies, and eluant, eluent is ethyl acetate: petroleum ether (1:10), obtains 6.54g target product, yield 87.2%.
Properties of CYCLOPENTYL PHENYL KETONE
Boiling point: | 136-140°C 16mm |
Density | 1,036 g/cm3 |
refractive index | 1.5440 |
Flash point: | >110°C |
storage temp. | Sealed in dry,Room Temperature |
solubility | Chloroform, Methanol (Slightly) |
form | Oil |
Specific Gravity | 1.04 |
color | Pale Yellow |
BRN | 2045903 |
CAS DataBase Reference | 5422-88-8(CAS DataBase Reference) |
EPA Substance Registry System | Methanone, cyclopentylphenyl- (5422-88-8) |
Safety information for CYCLOPENTYL PHENYL KETONE
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for CYCLOPENTYL PHENYL KETONE
InChIKey | VYDIMQRLNMMJBW-UHFFFAOYSA-N |
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