CYCLO (ARG-GLY-ASP-D-PHE-LYS)
- CAS NO.:161552-03-0
- Empirical Formula: C27H41N9O7
- Molecular Weight: 603.67
- MDL number: MFCD00937400
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-17 16:00:36
What is CYCLO (ARG-GLY-ASP-D-PHE-LYS)?
The Uses of CYCLO (ARG-GLY-ASP-D-PHE-LYS)
Cyclo (-RGDfK) Trifluoroacetic Acid Salt is a potent inhibitor of αvβ3 integrin. Used in tumor therapy due to the targeting of the VEGFR2 gene by sRNA.
Biological Activity
in one study where this peptide was labeled with 125i, it was found to bind specifically and with high affinity to αvβ3 receptors on neovascular blood vessel sections of different major human cancers. the integrin alpha(iib)beta(3)-specific cyclic hexapeptide contains an arg-gly-asp (rgd) sequence.
Properties of CYCLO (ARG-GLY-ASP-D-PHE-LYS)
Melting point: | 191℃ (decomposition) |
Density | 1.47±0.1 g/cm3(Predicted) |
storage temp. | Store at -20°C |
solubility | ≥30.19 mg/mL in DMSO; insoluble in EtOH; ≥59.2 mg/mL in H2O |
form | Powder |
pka | 4.01±0.10(Predicted) |
color | White to off-white |
Safety information for CYCLO (ARG-GLY-ASP-D-PHE-LYS)
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for CYCLO (ARG-GLY-ASP-D-PHE-LYS)
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