CK-0157869
Synonym(s):2-(3-Bromophenyl)-3-(2,4-dimethoxyphenyl)-4-thiazolidinone;CK 869;CK-0157869
- CAS NO.：388592-44-7
- Empirical Formula: C17H16BrNO3S
- Molecular Weight: 394.28
- MDL number: MFCD01844129
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 23:02:33
What is CK-0157869?
Description
CK 869 is an inhibitor of actin polymerization via inhibition of the actin-related protein 2/3 (Arp2/3) complex, leading to reduced cell motility rate and rearrangement of F-actin in M-1 cells. It inhibits comet tail formation by L. monocytogenes with an IC50 value of 7 μM. It also impairs cell adhesion and cell spreading in MCF10A human breast epithelial cells.
The Uses of CK-0157869
CK-869 binds to the Arp2/3 complex and inhibits nucleation. The Arp2/3 complex is involved with cell motility and F-actin reorganization in M-1 cells.
The Uses of CK-0157869
CK-869 has been used as an Arp2/3 complex inhibitor:
- to treat cultured mammalian cells and study its in vitro and in vivo effects on microtubule assembly
- to induce membrane blebbing in HT1080 fibrosarcoma cells
- to treat KDM3A-null cells and study the relation between actin dynamics and ciliogenesis
Biochem/physiol Actions
CK-0157869 (CK-869) prevents microtubule (MT) assembly, free of Arp2/3 complex.
Properties of CK-0157869
| storage temp. | 2-8°C |
| solubility | DMSO: soluble10mg/mL, clear |
| form | powder |
| color | white to light gray |
Safety information for CK-0157869
| Signal word | Danger |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07  Health Hazard GHS08  Environment GHS09 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H361:Reproductive toxicity H372:Specific target organ toxicity, repeated exposure H410:Hazardous to the aquatic environment, long-term hazard |
| Precautionary Statement Codes |
P201:Obtain special instructions before use. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P312:Call a POISON CENTER or doctor/physician if you feel unwell. P301+P330+P331:IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
Computed Descriptors for CK-0157869
New Products
4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 4-(Dimethylamino)tetrahydro-2H-pyran-4-carbonitrile 4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID 4-Aminotetrahydropyran-4-carbonitrile Hydrochloride (R)-3-Aminobutanenitrile Hydrochloride 5-Bromo-2-nitropyridine Nimesulide BP Aceclofenac IP/BP/EP Diclofenac Sodium IP/BP/EP/USP Mefenamic Acid IP/BP/EP/USP Ornidazole IP Diclofenac Potassium 3-Bromopyrazole (3aR,4R,5R,6aS)-hexahydro-5-Triethyl silyloxy-4-((E)-3-oxo-5-phenylpent-1- enyl)cyclopenta[b]furan-2-one. 1-Chlorocarbonyl-4-piperidinopiperidine 1-Bromo-4-phenyl-2-Butanone 4-Amino-2-fluoro-N-methylbenzamide 1,1'-Carbonyldiimidazole SODIUM AAS SOLUTION ZINC AAS SOLUTION BUFFER SOLUTION PH 10.0(BORATE) GOOCH CRUCIBLE SINTERED AQUANIL 5 BERYLLIUM AAS SOLUTIONRelated products of tetrahydrofuran
You may like
-
CK-869 CAS 388592-44-7View Details
388592-44-7 -
Dimethyl [2-oxo-3-[3-(trifluoromethyl)phenoxy]propyl]phosphonate 99%View Details
54094-19-8 -
85-81-4 99%View Details
85-81-4 -
208111-98-2 (3aR,4R,5R,6aS)-5-(Benzoyloxy)hexahydro-4-[(1E)-3-oxo-4-[3-(trifluoromethyl)phenoxy]-1-buten- 1-yl]-2H-cyclopenta[b]furan-2-one 99%View Details
208111-98-2 -
2033-24-1 99%View Details
2033-24-1 -
Meldrums acid 2033-24-1 99%View Details
2033-24-1 -
Cyaclopentane carboxylic acid 99%View Details
3400-45-1 -
2-Aminopyridine 504-29-0 99%View Details
504-29-0
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.