citreoviridin

CAS NO.：25425-12-1
Empirical Formula: C23H30O6
Molecular Weight: 402.48
MDL number: MFCD28015902
SAFETY DATA SHEET (SDS)
Update Date: 2023-06-08 09:01:59

What is citreoviridin?

Chemical properties

Yellow powder

The Uses of citreoviridin

Citreoviridin is the dominant analogue of a family of tetraene mycotoxins with potent neurotoxic effects, produced by several species of Aspergillus and Penicillium. Citreoviridin inhibits mitochondrial ATPase and is a causative agent of cardiac beriberi.

The Uses of citreoviridin

Citreoviridin is a mycotoxin isolated from several Penicillium species that has been shown to inhibit the mitochondrial ATP synthetase system. It inhibits soluble ATPase (KD = 4.1 μM), ADP-stimulated respiration in isolated rat liver mitochondria (KD = 0.15 μM), and ATP-driven reduction of NAD+ by succinate (KD = 2 μM). Citreoviridin has been used to target ectopic ATPase activity in cancer cells in order to modulate the metabolic activity associated with tumorigenesis.[Cayman Chemical]

What are the applications of Application

Citreoviridin is a mycotoxin and potent inhibitor of mitochondrial ATPase

Definition

ChEBI: Citreoviridin is a member of 2-pyranones.

Properties of citreoviridin

Melting point:	107-111℃
Boiling point:	444.62°C (rough estimate)
Density	1.1271 (rough estimate)
refractive index	1.4593 (estimate)
storage temp.	2-8°C
solubility	DMSO: 10 mg/ml; Ethanol: 10 mg/ml
pka	13.67±0.70(Predicted)
form	Yellow to orange powder.
Stability:	Light Sensitive

Safety information for citreoviridin

Signal word	Danger
Pictogram(s)	Skull and Crossbones Acute Toxicity GHS06 Health Hazard GHS08
GHS Hazard Statements	H300:Acute toxicity,oral H311:Acute toxicity,dermal H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H331:Acute toxicity,inhalation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation H361:Reproductive toxicity
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P311:Call a POISON CENTER or doctor/physician. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.