CIS-ENTACAPONE
Synonym(s):(Z)-Entacapone;(2Z)-2-Cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide
- CAS NO.：145195-63-7
- Empirical Formula: C14H15N3O5
- Molecular Weight: 305.29
- MDL number: MFCD00869878
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-07-12 16:52:05
What is CIS-ENTACAPONE?
Description
cis-Entacapone is a metabolite of the catechol-O-methyltransferase (COMT) inhibitor entacapone . It is also a potential impurity found in commercial preparations of entacapone and a degradant of entacapone formed by UV light exposure.
Chemical properties
Orange Solid
The Uses of CIS-ENTACAPONE
cis-Entacapone (Entacapone EP Impurity A) is the (Z)-Isomer of Entacapone polymorphic form B. Antiparkinsonian.
What are the applications of Application
cis-Entacapone is a (Z)-Isomer of Entacapone polymorphic form B
Definition
ChEBI: 2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide is a hydroxycinnamic acid.
Properties of CIS-ENTACAPONE
| Melting point: | 142-144°C |
| Boiling point: | 526.6±50.0 °C(Predicted) |
| Density | 1.392±0.06 g/cm3(Predicted) |
| storage temp. | Hygroscopic, -20°C Freezer, Under Inert Atmosphere |
| solubility | Dichloromethane (Slightly), Methanol (Slightly) |
| form | neat |
| pka | 5.15±0.50(Predicted) |
| color | Yellow to Orange |
Safety information for CIS-ENTACAPONE
Computed Descriptors for CIS-ENTACAPONE
New Products
(S)-3-Aminobutanenitrile hydrochloride 4-Methylphenylacetic acid N-Boc-D-alaninol N-BOC-D/L-ALANINOL Tert-butyl bis(2-chloroethyl)carbamate 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin- 2(1H)-one Furan-2,5-Dicarboxylic Acid Tropic acid 1-Bromo-3,5-Di-Tert-Butylbenzene S-2-CHLORO PROPIONIC ACID ETHYL ISOCYANOACETATE 2-Bromo-1,3-Bis(Dimethylamino)Trimethinium Hexafluorophosphate 4-IODO BENZOIC ACID 3-NITRO-2-METHYL ANILINE 1-(2,4-DICHLOROPHENYL) ETHANAMINE (2-Hydroxyphenyl)acetonitrile 4-Bromopyrazole 2-(Cyanocyclohexyl)acetic acid 4-methoxy-3,5-dinitropyridine 1-(4-(aminomethyl)benzyl)urea hydrochloride 2-aminopropyl benzoate hydrochloride diethyl 2-(2-((tertbutoxycarbonyl)amino) ethyl)malonate tert-butyl 4- (ureidomethyl)benzylcarbamate Ethyl-2-chloro((4-methoxyphenyl)hydrazono)acetateRelated products of tetrahydrofuran
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