Cidofovir
Synonym(s):(S)-1-[3-hydroxy-2-(phosphonylmethoxy)propyl]cytosine;(S)-HPMPC; Cidovir;HPMPC;Vistide
- CAS NO.：149394-66-1
- Empirical Formula: C8H14N3O6P
- Molecular Weight: 279.187021
- EINECS: 814-987-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-09-29 20:12:18
What is Cidofovir?
Chemical properties
White Solid
The Uses of Cidofovir
An injectable antiviral medication for the treatment of cytomegalovirus (CMV) retinitis in patients with AIDS. It suppresses CMV replication by selective inhibition of viral DNA polymerase and therefo re prevention of viral replication and transcription. It is used in the treatment of acyclovir resistant herpes as well as a complementary intralesional therapy against papillomatosis caused by human papillomavirus (HPV).
The Uses of Cidofovir
Cidofovir Dihydrate is used in treatment of pain and combination with analgesics.
Definition
ChEBI: The dihydrate of the anhydrous form of cidofovir. A nucleoside analogue, it is an injectable antiviral used for the treatment of cytomegalovirus (CMV) retinitis in AIDS patients.
brand name
Vistide (Gilead Sciences).
Properties of Cidofovir
| Melting point: | >250°C (dec.) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| solubility | DMSO (Sparingly), Water (Sparingly) |
| form | Solid |
| color | White |
| InChI | InChI=1/C8H14N3O6P/c9-7-1-2-11(8(13)10-7)3-6(4-12)17-5-18(14,15)16/h1-2,6,12H,3-5H2,(H2,9,10,13)(H2,14,15,16)/t6-/s3 |
Safety information for Cidofovir
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Cidofovir
| InChIKey | VWFCHDSQECPREK-ISZMHOAENA-N |
| SMILES | N1C(=O)N(C[C@@H](CO)OCP(O)(=O)O)C=CC=1N |&1:5,r| |
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