Contact us: +91 9550333722 040 - 40102781
Structured search
India
Choose your country
Different countries will display different contents
Try our best to find the right business for you.
My chemicalbook

Welcome back!

HomeProduct name listchlorthenoxazine

chlorthenoxazine

  • CAS NO.:132-89-8
  • Empirical Formula: C12H8ClNO
  • Molecular Weight: 217.65102
  • MDL number: MFCD00012095
  • EINECS: 2050823
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-19 23:02:33
chlorthenoxazine  Structural

What is chlorthenoxazine ?

Originator

Reugaril ,Farber ,Italy ,1966

Definition

ChEBI: Chlorthenoxazine is a benzoxazine.

Manufacturing Process

A mixture of 4 liters chloroform and 1,050 cc ethanol was saturated with dry hydrogen chloride gas at -5°C to +5°C in a vessel having a net volume of 15 liters and provided with a stirring device, reflux cooler, gas feed line, thermometer and dropping funnel. 455 g acrolein which had been precooled to 0°C were added dropwise to the solution over a period of 1 to 2 hours while maintaining the temperature below +5°C and vigorously stirring. 1,070 g salicylamide and 1,080 g glacial acetic acid were added to the resulting solution of beta-chloropropionaldehyde acetal, thereby forming a suspension which was heated to 60°C while stirring. A clear solution was formed which was maintained at 60°C for an additional hour. The solution was allowed to cool to about 40°C and was then washed with water by passing a strong stream of water under the surface of the chloroform and continuously withdrawing the upper phase. When the water had reached a pH of 3-4, the precipitated reaction product was separated by vacuum filtration. The chloroform phase of the filtrate was evaporated under a weak vacuum and the residue was combined with the precipitate first obtained. The combined products were stirred with 2 liters of a 5% sodium hydroxide solution. The raw reaction product was then washed with water, dried and recrystallized from ethanol. The product had the melting point of 146°C to 147°C (decomposition). The yield was 1,260 g, corresponding to 76% of the theoretical yield.

Therapeutic Function

Antipyretic, Analgesic

Properties of chlorthenoxazine

Melting point: 146-147° (dec)
Boiling point: 303°C (rough estimate)
Density  1.2414 (rough estimate)
refractive index  1.5500 (estimate)
storage temp.  Store at -20°C
solubility  Soluble in DMSO
pka 12.70±0.40(Predicted)

Safety information for chlorthenoxazine

Computed Descriptors for chlorthenoxazine

Related products of tetrahydrofuran

You may like

Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.