CGP52421
- CAS NO.：179237-49-1
- Empirical Formula: C35H30N4O5
- Molecular Weight: 586.65
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-28 23:16:16
What is CGP52421?
The Uses of CGP52421
3-Hydroxy Midostaurin-d5 is the deuterium labelled 3-Hydroxy Midostaurin (H939985(M)). 3-Hydroxy Midostaurin is a metabolite of Midostaurin (M343760), a compound shown to possess antiproliferative characteristics via inhibition of protein kinase C, kinase insert domain receptor, and c-kit.
Biological Activity
3-Hydroxy Midostaurin (CGP 52421), a metabolite of PKC412, potently inhibits FMS-like tyrosine kinase 3 (FLT3) autophosphorylation with IC50s of 132 nM and 9.8 μM in culture medium and plasma, respectively. Compared to PKC412, 3-Hydroxy Midostaurin is less selective but more cytotoxic.
in vitro
CGP52421 (200, 400, 600, 800, 1000 nM) is more cytotoxic than PKC412 over the dose range 100 to 500 nM.
Properties of CGP52421
| Density | 1.53±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO |
| pka | 12.23±0.70(Predicted) |
| form | Solid |
| color | Light yellow to yellow |
Safety information for CGP52421
Computed Descriptors for CGP52421
New Products
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