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HomeProduct name listCefetamet hydrochloride

Cefetamet hydrochloride

  • CAS NO.:65052-63-3
  • Empirical Formula: C14H15N5O5S2
  • Molecular Weight: 397.43
  • MDL number: MFCD00864836
  • EINECS: 675-838-9
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-12-19 20:05:46
Cefetamet hydrochloride Structural

What is Cefetamet hydrochloride?

Description

Ceftazidime hydrochloride is an oral third-generation cephalosporin, which has the same antibacterial activity against gram-positive bacteria as cefixime, and is superior to cefaclor, especially against Streptococcus pneumoniae and Streptococcus pyogenes. It has obvious antibacterial activity against a variety of gram-negative bacteria such as Escherichia coli, Proteus, Klebsiella pneumoniae, Haemophilus influenzae, and Neisseria gonorrhoeae, especially against Serratia, indole-positive Proteus, Enterobacter The antibacterial activity of Citrobacter and Citrobacter was significantly enhanced.

The Uses of Cefetamet hydrochloride

Cefetamet is a third-generation cephalosporin antibiotic and the active agent of Cefeamet pivoxil (C242780) after hydrolysis.

What are the applications of Application

Cefetamet acid is a third-generation cephalosporin antibiotic

Definition

ChEBI: Cefetamet is a cephalosporin compound having methyl and [(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino side-groups; a cephalosporin antibiotic active against Neisseria gonorrhoeae.

Antimicrobial activity

A semisynthetic cephalosporin formulated for oral use as the prodrug ester, cefetamet pivoxyl. It is less active than cefaclor and cefadroxil against Staph. aureus, but as active against streptococci and more active against enterobacteria, H. influenzae and N. gonorrhoeae, including β-lactamase-producing strains. L. monocytogenes, C. difficile, Sten. maltophilia and Burk. cepacia are all resistant. It is resistant to hydrolysis by common plasmid-mediated enzymes.
The absolute bioavailability is about 50%. The plasma peak is delayed by food. Binding to plasma protein is about 20%. The volume of distribution approximates to the extracellular water. It is excreted into urine with a half-life of 2–2.5 h, principally in the glomerular filtrate. Elimination is linearly related to creatinine clearance. Side effects and uses are similar to those of other group 5 cephalosporins.

Properties of Cefetamet hydrochloride

Melting point: >178°C (dec.)
Density  1.83±0.1 g/cm3(Predicted)
storage temp.  Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility  DMSO (Slightly), Methanol (Slightly, Heated, Sonicated)
form  Solid
pka 3.11±0.50(Predicted)
color  White to Off-White
Stability: Hygroscopic
CAS DataBase Reference 65052-63-3(CAS DataBase Reference)

Safety information for Cefetamet hydrochloride

Computed Descriptors for Cefetamet hydrochloride

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