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HomeProduct name listCARNOSOL

CARNOSOL

Synonym(s):Picrosalvin

CARNOSOL Structural

What is CARNOSOL?

Description

Carnosol is a phenol that has been found in rosemary (R. officinalis) and has diverse biological activities. It decreases nitric oxide (NO) production in mouse peritoneal exudate macrophages when used at concentrations ranging from 6 to 25 μM. Carnosol scavenges peroxyl and hydroxyl radicals and inhibits lipid peroxidation in cell-free assays. It inhibits 5-lipoxygenase (5-LO; IC50 = 0.1 μM for the recombinant human enzyme) and the synthesis of leukotrienes in human polymorphonuclear leukocytes (PMNs; IC50 = 7 μM). In vivo, carnosol (200 mg/kg) reduces mammary DNA adduct formation and tumorigenesis in a rat model of DMBA-induced mammary tumorigenesis.

Chemical properties

White powder

The Uses of CARNOSOL

Carnosol is a phytopolyphenol found in Rosemary that functions as an antioxidant, antimicrobial, & anticarcinogen.

What are the applications of Application

Carnosol is a phytopolyphenol found in Rosemary that functions as an antioxidant, antimicrobial, & anticarcinogen

Definition

ChEBI: Carnosol is a diterpenoid.

Cytotoxicity

IC50 (μg/mL): 65 (HL-60), 58 (K562), 50(Hep G2), 48 (MCF-7), 53 (MOLT-4)(Farimani et al. 2012)
IC50 (μg/mL): 61.46 (AGS) (Areche et al.2009)
IC50 (μg/mL): 2 (P388) (Aoyagi et al.2006)
IC50 (μg/mL): 1.19 (A2780), 3.30(SW1573), 8.59 (WiDr), 7.93 (T-47D),1.29 (HBL-100) (Guerrero et al. 2006).

Properties of CARNOSOL

Melting point: 240~242℃
Boiling point: 524.8±50.0 °C(Predicted)
Density  1.26±0.1 g/cm3(Predicted)
storage temp.  Sealed in dry,Store in freezer, under -20°C
solubility  DMSO:66.0(Max Conc. mg/mL);199.74(Max Conc. mM)
form  neat
pka 8.91±0.40(Predicted)
form  Solid
color  White

Safety information for CARNOSOL

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H317:Sensitisation, Skin
Precautionary Statement Codes P280:Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:IF ON SKIN: wash with plenty of soap and water.

Computed Descriptors for CARNOSOL

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