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HomeProduct name listCARBOXYPEPTIDASE B

CARBOXYPEPTIDASE B

Synonym(s):Peptidyl-L-lysine(L-arginine) hydrolase;Protaminase

  • CAS NO.:9025-24-5
  • Empirical Formula: C31H38N4O7S
  • Molecular Weight: 610.72102
  • MDL number: MFCD00081476
  • EINECS: 232-788-9
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-10-26 18:06:12
CARBOXYPEPTIDASE B Structural

What is CARBOXYPEPTIDASE B?

The Uses of CARBOXYPEPTIDASE B

The enzyme from Sigma has been used to develop homogeneous time-resolved fluorescence (HTRF) assay for measuring carboxypeptidase B activity in a miniaturized high-throughput screening format. It has been used to evaluate the impact of the C-terminal lysine(s) in human plasminogen binding to Bifidobacterium. The effect of treatment with carboxypeptidase B, which is a C-terminal lysine-specific endopeptidase, is measured using flow cytometry analysis.

The Uses of CARBOXYPEPTIDASE B

Carboxypeptidase B from Sigma has been used as a reference for assaying carboxypeptidase activity in lysed pituitary granules derived from the anterior and intermediate lobes of rat. The enzyme has also been used to digest plasma samples by removing C-terminal basic amino acids, to get a distinct band for each allotype during C4 electrophoresis.

General Description

Native carboxypeptidase B catalyzes the release of C-terminal from basic amino acids, arginine, lysine, or ornithine from polypeptides. Inhibited by EDTA and other Zn2+ chelators.

Biochem/physiol Actions

Carboxypeptidase B is a proteolytic enzyme capable of rapidly hydrolyzing peptide bonds to release certain carboxyl-terminal basic amino acids from peptides and proteins. Its molecular mass is 34,300±600 Da. It contains one non-dialyzable gram atom of zinc per mole. The enzyme activity is inhibited by metal chelating agents 1, 10-phenanthroline, 8-hydroxyquinoline-5-sulfonic acid, and 2,2′-dipyridyl.

Properties of CARBOXYPEPTIDASE B

storage temp.  -20°C
form  powder
color  white

Safety information for CARBOXYPEPTIDASE B

Signal word Danger
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
ghs
Health Hazard
GHS08
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H334:Sensitisation, respiratory
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for CARBOXYPEPTIDASE B

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