1-Chloroethyl (4-nitrophenyl) carbonate
- CAS NO.:101623-69-2
- Empirical Formula: C9H8ClNO5
- Molecular Weight: 245.62
- MDL number: MFCD19441847
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-12-28 18:13:10
What is 1-Chloroethyl (4-nitrophenyl) carbonate?
The Uses of 1-Chloroethyl (4-nitrophenyl) carbonate
A clear, colourless to pale yellow liquid used as an intermediate in Gabapentin, an API.
Synthesis
To an ice cold reaction mixture containing p-nitrophenol (1.39 g, 10 mmol) and pyridine (0.81 g, 10 mmol) in dichloromethane (60 mL) was added 1-chloroethyl chloroformate (1.2 mL, 11 mmol). The mixture was stirred at 0° C for 30 min and then at room temperature for 1 hour. After removing the solvent under reduced pressure, the residue was dissolved in ether, washed with water, 10percent citric acid and water. The ether layer was dried over Na2SO4and evaporated under reduced pressure to give 2.4 g (97percent) of 1-Chloroethyl (4-nitrophenyl) carbonate as an off-white solid.
Properties of 1-Chloroethyl (4-nitrophenyl) carbonate
Melting point: | 71.0-71.7 °C(Solv: hexane (110-54-3)) |
Boiling point: | 359.1±42.0 °C(Predicted) |
Density | 1.415±0.06 g/cm3(Predicted) |
storage temp. | 2-8°C |
Safety information for 1-Chloroethyl (4-nitrophenyl) carbonate
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral |
Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 1-Chloroethyl (4-nitrophenyl) carbonate
Abamectin manufacturer
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product: 101623-69-2 1-Chloroethyl-p-nitrophenyl carbonate 99%
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