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HomeProduct name listCAPTOPRIL DISULFIDE

CAPTOPRIL DISULFIDE

Synonym(s):(2S)-1-[(2S)-3-(Acetylsulfanyl)-2-methylpropanoyl]pyrrolidine-2-carboxylic acid;N-[3-(Acetylthio)-(2S)-methylpropionyl]-L-proline;1,1′-[Dithiobis[(2S)-2-methyl-1-oxo-3,1-propanediyl]]bis-L-proline;Acetylcaptopril

CAPTOPRIL DISULFIDE Structural

What is CAPTOPRIL DISULFIDE?

Description

Captopril disulfide is a metabolite and symmetrical disulfide form of the angiotensin converting enzyme (ACE) inhibitor captopril . Captopril disulfide is the main degradation product of captopril and is formed by oxidation. It is a potential impurity in commercial preparations of captopril. Captopril disulfide inhibits angiotensin I-induced increases in mean arterial pressure in anesthetized dogs (ID50 = 0.231 mg/kg, i.v.).

Chemical properties

White Solid

The Uses of CAPTOPRIL DISULFIDE

Captopril Disulfide (Captopril EP Impurity A) is a metabolite of Captopril. A new antihypertensive agent.

What are the applications of Application

Captopril Disulfide is a potent inhibitor of angiotensin-converting enzyme (ACE)

Definition

ChEBI: An organic disulfide in which the disulfide bond links two units of captopril. It is a secondary metabolite of captopril.

Properties of CAPTOPRIL DISULFIDE

Melting point: 224-226°C
Boiling point: 714.8±60.0 °C(Predicted)
Density  1.383±0.06 g/cm3(Predicted)
storage temp.  -20°C Freezer
solubility  DMSO (Slightly), Ethanol (Slightly, Sonicated), Methanol (Slightly, Sonicated)
form  neat
pka 3.29±0.20(Predicted)
form  Solid
color  White to Off-White

Safety information for CAPTOPRIL DISULFIDE

Computed Descriptors for CAPTOPRIL DISULFIDE

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