CAPSANTHIN
Synonym(s):(3R,3′S,5′R)-3,3′-Dihydroxy-β,κ-caroten-6′-one
- CAS NO.:465-42-9
- Empirical Formula: C40H56O3
- Molecular Weight: 584.87
- MDL number: MFCD31726206
- EINECS: 207-364-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-08-28 13:53:24
What is CAPSANTHIN?
Description
Capsanthin is a carotenoid that has been found in C. annuum and has diverse biological activities. It reduces hydrogen peroxide-induced production of reactive oxygen species (ROS) and phosphorylation of ERK and p38 and prevents hydrogen peroxide-induced inhibition of gap junction intercellular communication in WB-F344 rat liver epithelial cells. Capsanthin (0.2 mg/animal) reduces the number of colonic aberrant crypt foci and preneoplastic lesions in a rat model of N-methylnitrosourea-induced colon carcinogenesis. It also reduces ear edema in a mouse model of inflammation induced by phorbol 12-myristate 13-acetate (TPA; ).
The Uses of CAPSANTHIN
Capsanthin may be used as an analytical reference standard for the quantification of the analyte in red pepper powder, red pepper fruits, paprika and oleoresin using chromatography techniques.
The Uses of CAPSANTHIN
antineoplastic
What are the applications of Application
Capsanthin is a natural carotenoid compound
Definition
ChEBI: Capsanthin is a carotenone. It has a role as a plant metabolite.
General Description
Capsanthin, also known as the red pepper carotenoid, is one of the major color pigments of paprika oleoresin, an oil-soluble extract, isolated from the fruits of Capsicum annum Linn or Capsicum frutescens. It is widely used as a color additive in food industries across the globe. The photoprotective effect of capsanthin protects human dermal fibroblasts against UVB induced DNA damage.
Hazard
A poison by skin contact.
Biochem/physiol Actions
Capsanthin is a potential nutraceutical, is found in green vegetables and is a constituent of paprika and asparagus. Capsanthin has been shown to exhibit anti-proliferative function.
Safety Profile
A poison by skin contact. When heated to decomposition it emits acrid smoke and irritating vapors.
Purification Methods
Possible impurities are zeaxanthin and capsorubin (below). Purify capsanthin by chromatography on a column of alumina (grade IV) and develop with 0.2% EtOH in *C6H6. It
Properties of CAPSANTHIN
Melting point: | 177-178℃ |
Boiling point: | 581.82°C (rough estimate) |
alpha | Cd +36° (chloroform) |
Density | 1.012 |
refractive index | 1.4960 (estimate) |
storage temp. | -20°C |
solubility | Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly) |
form | Solid |
pka | 14.85±0.60(Predicted) |
color | Dark Red to Very Dark Brown |
λmax | λ: 467-471 nm Amax |
Merck | 14,1769 |
Stability: | Light Sensitive, Temperature Sensitive |
Safety information for CAPSANTHIN
Computed Descriptors for CAPSANTHIN
Abamectin manufacturer
HRV Global Life Sciences
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