C2 CERAMIDE
Synonym(s):C2 Ceramide (d18:1/2:0);N-acetoyl-D-erythro-sphingosine;(2S,3R,4E)-2-(Acetylamino)-4-octadecene-1,3-diol;N-Acetoyl-D -erythro-sphingosine;Acetyl ceramide
- CAS NO.:3102-57-6
- Empirical Formula: C20H39NO3
- Molecular Weight: 341.53
- MDL number: MFCD00153903
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-01 18:44:47
What is C2 CERAMIDE?
Description
C2 ceramide is a cell-
Chemical properties
White Crystalline Solid
The Uses of C2 CERAMIDE
A biologically active, cell permeable, but nonphysiologic ceramide analog. It inhibits cell proliferation and induces monocytic differentiation of HL-60 cells and induces apoptosis. It stimulates protein phosphatase 2A and activates MAP Kinase2
The Uses of C2 CERAMIDE
Inhibits cell proliferation and induces monocytic differentiation of HL-60 cells. Activates protein phosphatases
What are the applications of Application
C2 Ceramide is a ser/thr protein phosphatase activator and cell-permeable analog of naturally occurring ceramides.
Definition
ChEBI: N-acetylsphingosine is a N-acylsphingosine that has an acetamido group at position 2.
Biological Activity
A potent modulator of cell proliferation and differentiation. Activates protein phosphatase-1 (PP1) and -2A (PP2A), as well as ceramide-activated protein phosphatase (CAPP) in vitro .
Biochem/physiol Actions
Cell-permeable, biologically active ceramide. It induces differentiation and apoptosis in cells and has been shown to activate protein phosphatases.
storage
Desiccate at -20°C
References
1) Minano et al. (2008), C2-ceramide mediates cerebellar granule cells apoptosis by activation of caspases-2, -9, and -3; J. Neurosci. Res., 86 1734 2) Prinetti et al. (1997), Involvement of a ceramide activated protein phosphatase in the differentiation of neuroblastoma Neuro2a cells; FEBS Lett., 414 475 3) Zhang et al. (1997), Kinase suppressor of Ras is ceramide-activated protein kinase; Cell, 89 63 4) Matsuzaka et al. (2016) Characterization and Functional Analysis of Extracellular Vesicles and Muscle-Abundant miRNAs (miR-1, miR-133a, and miR-206) in C2C12 Myocytes and mdx Mice; PLoS One 11(12) e0167811 [Focus Biomolecules Citation] 5) Matsuzaka et al. (2016) Characterization and functional analysis of extracellular vesicles and muscle-abundant miRNA in C2C12 myocytes and Mdx mice; PLoS One 11(12) e0167811 [Focus Biomolecules Citation]
Properties of C2 CERAMIDE
Melting point: | 93-96 °C |
Boiling point: | 477.13°C (rough estimate) |
Density | 1.0283 (rough estimate) |
refractive index | 1.5614 (estimate) |
storage temp. | −20°C |
solubility | DMSO: soluble |
form | powder |
pka | 13.50±0.20(Predicted) |
color | white |
Stability: | Moisture Sensitive |
Safety information for C2 CERAMIDE
Computed Descriptors for C2 CERAMIDE
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