C-(1H-INDOL-5-YL)-METHYLAMINE
Synonym(s):Indole-5-methanamine
- CAS NO.:81881-74-5
- Empirical Formula: C9H10N2
- Molecular Weight: 146.19
- MDL number: MFCD01719220
- SAFETY DATA SHEET (SDS)
What is C-(1H-INDOL-5-YL)-METHYLAMINE?
The Uses of C-(1H-INDOL-5-YL)-METHYLAMINE
5-(AMinoMethyl)indole has been used as reactant for preparation of:• and HIV-1 integrase inhibitors targeting the catalytic domain and its ability for interaction with LEDGF/p751•
The Uses of C-(1H-INDOL-5-YL)-METHYLAMINE
5-(Aminomethyl)indole is used in the synthesis of Vigabatrin (V253000) bioisosteres as inhibitors of γ-aminobutyric acid aminotransferase (GABA-AT) inhibitors.
The Uses of C-(1H-INDOL-5-YL)-METHYLAMINE
Reactant for preparation of:
- HIV-1 integrase inhibitors targeting the catalytic domain and its ability for interaction with LEDGF/p75
- Inhibitors of Gli1-mediated transcription in the Hedgehog pathway
- SCIO-469-like compounds for the inhibition of p38 MAP kinase
- 4-(indol-5-ylamino)thieno[2,3-b]pyridine-5-carbonitriles as protein kinase c theta (PKC θ) inhibitors
- Non-covalent thrombin inhibitors
Properties of C-(1H-INDOL-5-YL)-METHYLAMINE
Melting point: | 114-122 °C |
Boiling point: | 335.6±17.0 °C(Predicted) |
Density | 1.199±0.06 g/cm3(Predicted) |
storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
pka | 17.07±0.30(Predicted) |
Safety information for C-(1H-INDOL-5-YL)-METHYLAMINE
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for C-(1H-INDOL-5-YL)-METHYLAMINE
Related products of tetrahydrofuran
C-(2,3-DIMETHYL-1H-INDOL-5-YL)-METHYLAMINE
5-CARBOXAMIDOTRYPTAMINE, [1,2-3H]-
K-252C
N-ethoxycarbonyl-7-oxostaurosporine
5-carboxamidotryptamine maleate salt
2,3-DIMETHYL-1 H-INDOLE-5-CARBOXYLIC ACID HYDRAZIDE
TAN 999
2-CHLORO-N-(2,3-DIMETHYL-1H-INDOL-5-YLMETHYL)-ACETAMIDE
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