C-(1H-INDOL-5-YL)-METHYLAMINE
Synonym(s):Indole-5-methanamine
- CAS NO.：81881-74-5
- Empirical Formula: C9H10N2
- Molecular Weight: 146.19
- MDL number: MFCD01719220
- SAFETY DATA SHEET (SDS)
What is C-(1H-INDOL-5-YL)-METHYLAMINE?
The Uses of C-(1H-INDOL-5-YL)-METHYLAMINE
5-(AMinoMethyl)indole has been used as reactant for preparation of:• and HIV-1 integrase inhibitors targeting the catalytic domain and its ability for interaction with LEDGF/p751•
The Uses of C-(1H-INDOL-5-YL)-METHYLAMINE
5-(Aminomethyl)indole is used in the synthesis of Vigabatrin (V253000) bioisosteres as inhibitors of γ-aminobutyric acid aminotransferase (GABA-AT) inhibitors.
The Uses of C-(1H-INDOL-5-YL)-METHYLAMINE
Reactant for preparation of:
- HIV-1 integrase inhibitors targeting the catalytic domain and its ability for interaction with LEDGF/p75
- Inhibitors of Gli1-mediated transcription in the Hedgehog pathway
- SCIO-469-like compounds for the inhibition of p38 MAP kinase
- 4-(indol-5-ylamino)thieno[2,3-b]pyridine-5-carbonitriles as protein kinase c theta (PKC θ) inhibitors
- Non-covalent thrombin inhibitors
Properties of C-(1H-INDOL-5-YL)-METHYLAMINE
| Melting point: | 114-122 °C |
| Boiling point: | 335.6±17.0 °C(Predicted) |
| Density | 1.199±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| pka | 17.07±0.30(Predicted) |
Safety information for C-(1H-INDOL-5-YL)-METHYLAMINE
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for C-(1H-INDOL-5-YL)-METHYLAMINE
New Products
4-Aminotetrahydropyran-4-carbonitrile Hydrochloride (R)-3-Aminobutanenitrile Hydrochloride 4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 4-(Dimethylamino)tetrahydro-2H-pyran-4-carbonitrile 3-((Dimethylamino)methyl)-5-methylhexan-2-one oxalate 1,4-Dioxa-8-azaspiro[4.5]decane 5-Bromo-2-nitropyridine Nimesulide BP Aceclofenac IP/BP/EP Mefenamic Acid IP/BP/EP/USP Diclofenac Sodium IP/BP/EP/USP Ornidazole IP Diclofenac Potassium SODIUM AAS SOLUTION ZINC AAS SOLUTION BUFFER SOLUTION PH 10.0(BORATE) GOOCH CRUCIBLE SINTERED AQUANIL 5 BERYLLIUM AAS SOLUTION 2-Bromo-1-(bromomethyl)-3-chloro-5-nitrobenzene 2-Bromo-3-nitroaniline N-(3-Hydroxypropyl)-N-methylacetamide 3-Bromo-6-chloropyridazine 4-ethyl-3-nitrobenzoic acidRelated products of tetrahydrofuran
![5-CARBOXAMIDOTRYPTAMINE, [1,2-3H]-](https://img.chemicalbook.in/StructureFile/ChemBookStructure2/GIF/CB6135313.gif)
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