BTS

Synonym(s):BTS - CAS 1576-37-0 - Calbiochem;N-Benzyl- p-toluenesulphonamide;N-Benzyl-p-toluenesulphonamide

CAS NO.：1576-37-0
Empirical Formula: C14H15NO2S
Molecular Weight: 261.34
MDL number: MFCD00159328
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-18 21:14:07

What is BTS?

Description

BTS is an inhibitor of skeletal muscle myosin II ATPase activity that reduces the affinity of ADP-myosin for actin. It inhibits calcium-stimulated ATPase activity of rabbit muscle myosin subfragment 1 (S1) in an actin-independent manner with an IC₅₀ value of approximately 5 μM. It is selective for calcium-stimulated myosin II over human platelet myosin II, kinesin, pyruvate kinase, and lactate dehydrogenase at 100 μM. BTS (2 μM) inhibits the activity of skeletal muscle myosin, reversibly reducing the sliding velocity of heavy meromyosin in a gliding-filament assay. It inhibits isometric calcium-activated tension in isolated fast-twitch rabbit psoas muscle fibers (IC₅₀ = ~3 μM) but not in isolated slow-twitch rat trabeculae and papillary cardiac muscle. BTS is also an intermediate in the synthesis of sulfonamides.

Chemical properties

White Solid

The Uses of BTS

A potent inhibitor of skeletal muscle Ca2+-stimulated myosin S1 ATPase (IC50 approx. 5uM) activity. Reversible blocks the gliding motility. Also weakens myosin interaction with F-actin. Does not affect platelet myosin II

The Uses of BTS

A potent inhibitor of calcium-stimulated myosin S1 ATPase

What are the applications of Application

BTS is a potent inhibitor of Ca2+-stimulated myosin S1 ATPase

Definition

ChEBI: 4-methyl-N-(phenylmethyl)benzenesulfonamide is a sulfonamide.

Synthesis Reference(s)

The Journal of Organic Chemistry, 28, p. 592, 1963 DOI: 10.1021/jo01037a523

Biological Activity

Selective inhibitor of the ATPase activity of skeletal muscle myosin II subfragment 1 (S1) (IC 50 ~ 5 mM). Reversibly blocks gliding motility and suppresses force and twitch production in fast skeletal muscle.

storage

Desiccate at RT

Properties of BTS

Melting point:	115 °C
Boiling point:	419.1±48.0 °C(Predicted)
Density	1.204±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Chloroform (Slightly), Dichloromethane, Ethyl Acetate (Slightly)
form	White crystalline solid
pka	11.54±0.30(Predicted)
color	White to Off-White
Sensitive	Light Sensitive
CAS DataBase Reference	1576-37-0(CAS DataBase Reference)

Safety information for BTS

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up.