brusatol
- CAS NO.：14907-98-3
- Empirical Formula: C26H32O11
- Molecular Weight: 520.53
- MDL number: MFCD01746220
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 15:53:33
What is brusatol?
The Uses of brusatol
Brusatol has been used to study the protective role of Nrf2 (nuclear factor, erythroid 2 like 2 ) in intestinal ischemia/reperfusion induced injury.
Definition
ChEBI: Brusatol is a triterpenoid.
Biochem/physiol Actions
Brusatol promotes Nrf2 (nuclear factor, erythroid 2 like 2 ) ubiquitination and degradation. Brusatol upregulates the expression of multiple ribosomal components and controls macromolecular complex function.
Properties of brusatol
| Boiling point: | 724.3±60.0 °C(Predicted) |
| Density | 1.46±0.1 g/cm3 (20 ºC 760 Torr) |
| storage temp. | -20°C |
| solubility | DMF: 1 mg/ml; DMSO: 1 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml |
| form | powder |
| pka | 8.81±0.70(Predicted) |
| color | white to beige |
| optical activity | [α]/D +35 to +44°, c = 0.5 in acetone |
Safety information for brusatol
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for brusatol
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