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HomeProduct name listBrodifacoum

Brodifacoum

  • CAS NO.:56073-10-0
  • Empirical Formula: C31H23BrO3
  • Molecular Weight: 523.42
  • MDL number: MFCD00084803
  • EINECS: 259-980-5
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-05-15 10:43:24
Brodifacoum Structural

What is Brodifacoum?

Description

Brodifacoum is a 4-hydroxycoumarin anticoagulant that acts as a vitamin K antagonist. It was registered as a pesticide in 1979 in the United States although in 2008 it was made a restricted use pesticide by the Environmental Protection Agency. This means it can only be used by certified pesticide applicators; however, the makers of D-Con which contains 0.005% brodifacoum by weight have challenged this and brodifacoum is currently available in D-Con and in various other pesticide products for the eradication of mice and rats although it is also used on larger mammals such as possums. Brodifacoum currently remains available to the general public.

Chemical properties

White Solid

The Uses of Brodifacoum

Brodifacoum is used to control rodents in and around buildings.

The Uses of Brodifacoum

Brodifacoum is a highly lethal vitamin K antagonist anticoagulant poison. In recent years, Broadifacoum, has become one of the world's most widely used pesticides.

The Uses of Brodifacoum

Rodenticide.

What are the applications of Application

Brodifacoum is a potent vitamin K antagonist anticoagulant agent

Definition

ChEBI: Brodifacoum is a member of benzenes, a ring assembly and a member of naphthalenes.

Hazard

Poison, anticoagulant.

Environmental Fate

Brodifacoum, like other hydroxycoumarins, interferes with the production of vitamin K–dependent coagulation factors. Vitamin K is a cofactor for the carboxylation of specific glutamic acid groups in coagulation factors II (prothrombin), VII, IX, and X. During this step, vitamin K is oxidized to vitamin K 2,3-epoxide. The regeneration of vitamin K by vitamin K 2,3-epoxide reductase is prevented by brodifacoum. As a result, dysfunctional decarboxy-coagulation factors are produced and coagulation is impaired. Brodifacoum is over 100 times more potent than warfarin on a molar basis in rats.

Metabolic pathway

The fate of brodifacoum in soils and plants has not been studied in detail because the compound is usually applied as a pelleted bait or in a wax block. This limits its dissipation in the environment. Studies in animals have been conducted as part of the assessment of safety and to investigate mode of action.

Degradation

Brodifacoum is a stable compound; no detectable degradation occurs at 50 °C or in direct sunlight over 30 days, though it is liable to some photodecomposition in solution.

Toxicity evaluation

Brodifacoum has a very low solubility in water and typically enters water through erosion where it is then found in the sediment. Brodifacoum concentrations are typically not measurable in water systems.
Products that contain brodifacoum as pesticide can remain toxic for a long period of time in the environment. The rate of decay of brodifacoum depends upon the amount of rainfall. As the product that contains brodifacoum degrades over time, the brodifacoum is absorbed into the soil. Soil bacteria degrade brodifacoum over weeks to months although soil type, temperature, and the presence of microorganisms that will degrade brodifacoum all influence the time it takes to degrade.

Properties of Brodifacoum

Melting point: 228-230°
Boiling point: 679.0±55.0 °C(Predicted)
Density  1.2940 (rough estimate)
vapor pressure  41 x l0-6 Pa (20 °C)
refractive index  1.4620 (estimate)
storage temp.  0-6°C
solubility  Chloroform (Slightly), DMSO (Slightly)
pka 5.0 (weak acid, est.)
form  neat
Water Solubility  0.24 mg l-1 (20 °C)
Merck  13,1363
BRN  8171403
CAS DataBase Reference 56073-10-0(CAS DataBase Reference)
EPA Substance Registry System Brodifacoum (56073-10-0)

Safety information for Brodifacoum

Signal word Danger
Pictogram(s)
ghs
Skull and Crossbones
Acute Toxicity
GHS06
ghs
Health Hazard
GHS08
ghs
Environment
GHS09
GHS Hazard Statements H372:Specific target organ toxicity, repeated exposure
H410:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes P202:Do not handle until all safety precautions have been read and understood.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P273:Avoid release to the environment.
P280:Wear protective gloves/protective clothing/eye protection/face protection.

Computed Descriptors for Brodifacoum

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