Brevilin A

Synonym(s):6-Angeloylplenolin;Brevelin A

CAS NO.：16503-32-5
Empirical Formula: C20H26O5
Molecular Weight: 346.42
MDL number: MFCD04034623
SAFETY DATA SHEET (SDS)
Update Date: 2024-07-02 08:55:41

What is Brevilin A?

The Uses of Brevilin A

Brevilin A can be used using a selective extraction method to obtain natural substances, and can also be applied to prepare derivatives to use for anti-cancer activity.

General Description

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

Enzyme inhibitor

This naturally occurring sesquiterpenoid (FW = 346.40 g/mol; CAS 16503- 32-5) from the volatile oils of the plant Centipeda minima inhibits (IC50 = 10 μg/mL) STAT3 phosphorylation in the Jak/STAT signal transduction pathway of A549R cells. Brevilin A showed high specificity on Janus Kinase activity and following STAT3 signaling without directly affecting some other signals, including p65, AKT and GSK-3β phosphorylation, as well as Src kinase activity. Brevilin A is also an antibiotic with activity against Giardia (IC50 = 16 μM) and Entamoeba histolitica (IC50 = 4–9 μM).

Properties of Brevilin A

Boiling point:	494.0±45.0 °C(Predicted)
Density	1.17±0.1 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO:100.0(Max Conc. mg/mL);288.67(Max Conc. mM)
form	A solid
color	White to off-white

Safety information for Brevilin A

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H317:Sensitisation, Skin
Precautionary Statement Codes	P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water.