BocNH-PEG12-CH2CH2NH2
- CAS NO.：1642551-09-4
- Empirical Formula: C31H64N2O14
- Molecular Weight: 688.84
- MDL number: MFCD31656921
- Update Date: 2024-10-25 23:13:37
What is BocNH-PEG12-CH2CH2NH2?
Biological Activity
Boc-NH-PEG12-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
Properties of BocNH-PEG12-CH2CH2NH2
| Boiling point: | 695.1±55.0 °C(Predicted) |
| Density | 1.088±0.06 g/cm3(Predicted) |
| pka | 12.23±0.46(Predicted) |
| form | Liquid |
| color | Colorless to light yellow |
Safety information for BocNH-PEG12-CH2CH2NH2
Computed Descriptors for BocNH-PEG12-CH2CH2NH2
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