Boc-Hyp-OH
Synonym(s):trans-N-(tert-Butoxycarbonyl)-4-hydroxy-L -proline;Boc-L -hydroxyproline
- CAS NO.：13726-69-7
- Empirical Formula: C10H17NO5
- Molecular Weight: 231.25
- MDL number: MFCD00053370
- EINECS: 604-011-7
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-12-18 14:08:52
What is Boc-Hyp-OH?
Chemical properties
White powder
The Uses of Boc-Hyp-OH
Boc-Hyp-OH is used in the preparation of hydroxyproline derivatives. It is an intermediate in the synthesis of Fosinopril-d5 Sodium Salt (F727803), the labeled analogue of Fosinopril Sodium Salt (F727800), a phosphinic acid containing angiotensin converting enzyme (ACE) inhibitor. Antihypertensive.
Biological Activity
Boc-Hyp-OH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). It is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
Properties of Boc-Hyp-OH
| Melting point: | 123-127 °C(lit.) |
| Boiling point: | 390.9±42.0 °C(Predicted) |
| alpha | -78 º (in H2O) |
| Density | 1.312±0.06 g/cm3(Predicted) |
| refractive index | -68 ° (C=1, MeOH) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. |
| form | Powder |
| pka | 3.80±0.40(Predicted) |
| color | White to off-white |
| optical activity | [α]20/D 53.5±2°, c = 1% in DMF |
| Water Solubility | very faint turbidity |
| BRN | 4295484 |
| CAS DataBase Reference | 13726-69-7(CAS DataBase Reference) |
| EPA Substance Registry System | (2S,4R)-1-tert-Butyl 4-hydroxy-1,2-pyrrolidinecarboxylate (13726-69-7) |
Safety information for Boc-Hyp-OH
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Boc-Hyp-OH
| InChIKey | BENKAPCDIOILGV-RQJHMYQMSA-N |
Boc-Hyp-OH manufacturer
Malladi Drugs AND Pharmaceuticals Limited
1Y
Phone:+91-9003056437
Whatsapp: +91 9003056437,+91 994063762
product: Boc-L-hydroxyproline 13726-69-7 99%
ARRKEM LIFE SCIENCES PRIVATE LIMITED
1Y
Phone:+91-8148739767
Whatsapp: +91-8148739767
product: 13726-69-7 (2S,4R)-1-(tert-butoxycarbonyl)-4- hydroxypyrrolidine-2-carboxylic acid; N-tert-butoxycarbonyl-L-trans-4- hydroxyproline 98%
Anand Agencies
Maharashtra
Phone:91-9075014125
Whatsapp: 91-9075014125
product: Boc-L-hydroxyproline
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