Boc-Hyp-OH

Synonym(s):trans-N-(tert-Butoxycarbonyl)-4-hydroxy-L-proline;Boc-L-hydroxyproline

CAS NO.：13726-69-7
Empirical Formula: C10H17NO5
Molecular Weight: 231.25
MDL number: MFCD00053370
EINECS: 604-011-7
SAFETY DATA SHEET (SDS)
Update Date: 2024-08-26 21:18:56

What is Boc-Hyp-OH?

Chemical properties

White powder

The Uses of Boc-Hyp-OH

Boc-Hyp-OH is used in the preparation of hydroxyproline derivatives. It is an intermediate in the synthesis of Fosinopril-d5 Sodium Salt (F727803), the labeled analogue of Fosinopril Sodium Salt (F727800), a phosphinic acid containing angiotensin converting enzyme (ACE) inhibitor. Antihypertensive.

Biological Activity

Boc-Hyp-OH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). It is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.

Properties of Boc-Hyp-OH

Melting point:	123-127 °C(lit.)
Boiling point:	390.9±42.0 °C(Predicted)
alpha	-78 º (in H2O)
Density	1.312±0.06 g/cm3(Predicted)
refractive index	-68 ° (C=1, MeOH)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form	Powder
pka	3.80±0.40(Predicted)
color	White to off-white
optical activity	[α]20/D 53.5±2°, c = 1% in DMF
Water Solubility	very faint turbidity
BRN	4295484
CAS DataBase Reference	13726-69-7(CAS DataBase Reference)
EPA Substance Registry System	(2S,4R)-1-tert-Butyl 4-hydroxy-1,2-pyrrolidinecarboxylate (13726-69-7)

Safety information for Boc-Hyp-OH

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.