Boc-6-AMinocaproic acid
Synonym(s):6-(Boc-amino)caproic acid;6-(Boc-amino)hexanoic acid;Boc-ε-Ahx-OH;Boc-6-aminohexanoic acid;N-ε-t.-Boc-ε-aminocaproic acid,t.-Boc-6-aminohexanoic acid
- CAS NO.:6404-29-1
- Empirical Formula: C11H21NO4
- Molecular Weight: 231.29
- MDL number: MFCD00037798
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-26 13:30:34
What is Boc-6-AMinocaproic acid?
Description
Boc-6-aminohexanoic acid is an alkane chain with terminal carboxlic acid and Boc-protected amino groups. The compound can be used as a PROTAC linker in the synthesis of PROTACs and other conjugation applications. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.
Chemical properties
Colorless crystal
The Uses of Boc-6-AMinocaproic acid
Protected ε-Aminocaproic Acid (A603015), Boc-6-AMinocaproic acid can be used in the preparatiom of esters of 6-aminohexanoic acid.
The Uses of Boc-6-AMinocaproic acid
6-(Boc-amino)hexanoic acid is used in the preparation of esters of 6-aminohexanoic acid as antibacterial agents. EACA is reported to inhibit chymotrypsin, Factor VIIa, lysine carboxy peptidase, plasmin, and plasminogen activator.
Properties of Boc-6-AMinocaproic acid
Melting point: | 35-40 °C |
Boiling point: | 166°C/0.3mmHg(lit.) |
Density | 1.065±0.06 g/cm3(Predicted) |
storage temp. | 2-8°C |
solubility | Chloroform, Ethyl Acetate |
form | Powder |
pka | 4.76±0.10(Predicted) |
color | White |
Water Solubility | Soluble in chloroform and ethyl acetate. Slightly soluble in water. |
BRN | 2049561 |
CAS DataBase Reference | 6404-29-1(CAS DataBase Reference) |
Safety information for Boc-6-AMinocaproic acid
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for Boc-6-AMinocaproic acid
Abamectin manufacturer
JSK Chemicals
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