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HomeProduct name listBoc-6-AMinocaproic acid

Boc-6-AMinocaproic acid

Synonym(s):6-(Boc-amino)caproic acid;6-(Boc-amino)hexanoic acid;Boc-ε-Ahx-OH;Boc-6-aminohexanoic acid;N-ε-t.-Boc-ε-aminocaproic acid,t.-Boc-6-aminohexanoic acid

Boc-6-AMinocaproic acid Structural

What is Boc-6-AMinocaproic acid?

Description

Boc-6-aminohexanoic acid is an alkane chain with terminal carboxlic acid and Boc-protected amino groups. The compound can be used as a PROTAC linker in the synthesis of PROTACs and other conjugation applications. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.

Chemical properties

Colorless crystal

The Uses of Boc-6-AMinocaproic acid

Protected ε-Aminocaproic Acid (A603015), Boc-6-AMinocaproic acid can be used in the preparatiom of esters of 6-aminohexanoic acid.

The Uses of Boc-6-AMinocaproic acid

6-(Boc-amino)hexanoic acid is used in the preparation of esters of 6-aminohexanoic acid as antibacterial agents. EACA is reported to inhibit chymotrypsin, Factor VIIa, lysine carboxy peptidase, plasmin, and plasminogen activator.

Properties of Boc-6-AMinocaproic acid

Melting point: 35-40 °C
Boiling point: 166°C/0.3mmHg(lit.)
Density  1.065±0.06 g/cm3(Predicted)
storage temp.  2-8°C
solubility  Chloroform, Ethyl Acetate
form  Powder
pka 4.76±0.10(Predicted)
color  White
Water Solubility  Soluble in chloroform and ethyl acetate. Slightly soluble in water.
BRN  2049561
CAS DataBase Reference 6404-29-1(CAS DataBase Reference)

Safety information for Boc-6-AMinocaproic acid

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405:Store locked up.

Computed Descriptors for Boc-6-AMinocaproic acid

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