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HomeProduct name listBIS(METHYLTHIO)GLIOTOXIN

BIS(METHYLTHIO)GLIOTOXIN

BIS(METHYLTHIO)GLIOTOXIN Structural

What is BIS(METHYLTHIO)GLIOTOXIN?

Description

Bis(methylthio)gliotoxin is a fungal metabolite originally isolated from G. deliquescens that has diverse biological activities. It inhibits PAF- and collagen-induced platelet aggregation in rabbit platelet-rich plasma (IC50s = 8.4 and 84.2 μM, respectively) but has no effect on arachidonic acid- or ADP-induced platelet aggregation (IC50s = >400 μM). Bis(methylthio)gliotoxin inhibits growth of HCT116 colon cancer cells (IC50 = 23.56 μM). It inhibits PAF-induced bronchoconstriction in guinea pigs when administered at a dose of 0.1 mg/kg and is less toxic to mice (LD50 = >500 mg/kg) than gliotoxin . Bis(methylthio)gliotoxin has been used as a serum biomarker in patients infected with invasive aspergillosis.

The Uses of BIS(METHYLTHIO)GLIOTOXIN

Bis(methylthio)gliotoxin (FR-49175) is an antiphagocytic metabolite.

What are the applications of Application

Bis(methylthio)gliotoxin (FR-49175) is an antiphagocytic metabolite and PAF receptor ligand known to inhibit platelet aggregation.

Enzyme inhibitor

This naturally occurring indole derivative (FW = 356.47 g/mol; CAS 74149- 38-5), also known as bis(methylthio)gliotoxin and dimethylgliotoxin, is a platelet-acivating factor (PAF) antagonist that inhibits PAF-induced platelet aggregation. The parent compound, gliotoxin is a dual inhibitor of famesyltransferase and geranylgeranyl-transferase. Bisdethiobis(methylthio)gliotoxin is a minor metabolite of Gliocladium deliquescens, Radiocarbon tracer experiments showed it is formed, apparently irreversibly, from gliotoxin. It has also been synthesized from gliotoxin by reduction and methylation. Bisdethio-bis(methylthio)gliotoxin also binds Cu+ and Ag+ ions.

Properties of BIS(METHYLTHIO)GLIOTOXIN

Boiling point: 669.6±55.0 °C(Predicted)
Density  1.49±0.1 g/cm3(Predicted)
storage temp.  −20°C
solubility  Chloroform (Slightly), Methanol (Slightly)
form  White solid.
pka 12.69±0.60(Predicted)
color  Off-White to Yellow

Safety information for BIS(METHYLTHIO)GLIOTOXIN

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P270:Do not eat, drink or smoke when using this product.
P271:Use only outdoors or in a well-ventilated area.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P312:Call a POISON CENTER or doctor/physician if you feel unwell.
P330:Rinse mouth.
P363:Wash contaminated clothing before reuse.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P403:Store in a well-ventilated place.

Computed Descriptors for BIS(METHYLTHIO)GLIOTOXIN

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