BIS(METHYLTHIO)GLIOTOXIN
- CAS NO.:74149-38-5
- Empirical Formula: C15H20N2O4S2
- Molecular Weight: 356.46
- MDL number: MFCD00133146
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-08 09:02:57
What is BIS(METHYLTHIO)GLIOTOXIN?
Description
Bis(methylthio)gliotoxin is a fungal metabolite originally isolated from G. deliquescens that has diverse biological activities. It inhibits PAF- and collagen-induced platelet aggregation in rabbit platelet-rich plasma (IC50s = 8.4 and 84.2 μM, respectively) but has no effect on arachidonic acid- or ADP-induced platelet aggregation (IC50s = >400 μM). Bis(methylthio)gliotoxin inhibits growth of HCT116 colon cancer cells (IC50 = 23.56 μM). It inhibits PAF-induced bronchoconstriction in guinea pigs when administered at a dose of 0.1 mg/kg and is less toxic to mice (LD50 = >500 mg/kg) than gliotoxin . Bis(methylthio)gliotoxin has been used as a serum biomarker in patients infected with invasive aspergillosis.
The Uses of BIS(METHYLTHIO)GLIOTOXIN
Bis(methylthio)gliotoxin (FR-49175) is an antiphagocytic metabolite.
What are the applications of Application
Bis(methylthio)gliotoxin (FR-49175) is an antiphagocytic metabolite and PAF receptor ligand known to inhibit platelet aggregation.
Enzyme inhibitor
This naturally occurring indole derivative (FW = 356.47 g/mol; CAS 74149- 38-5), also known as bis(methylthio)gliotoxin and dimethylgliotoxin, is a platelet-acivating factor (PAF) antagonist that inhibits PAF-induced platelet aggregation. The parent compound, gliotoxin is a dual inhibitor of famesyltransferase and geranylgeranyl-transferase. Bisdethiobis(methylthio)gliotoxin is a minor metabolite of Gliocladium deliquescens, Radiocarbon tracer experiments showed it is formed, apparently irreversibly, from gliotoxin. It has also been synthesized from gliotoxin by reduction and methylation. Bisdethio-bis(methylthio)gliotoxin also binds Cu+ and Ag+ ions.
Properties of BIS(METHYLTHIO)GLIOTOXIN
Boiling point: | 669.6±55.0 °C(Predicted) |
Density | 1.49±0.1 g/cm3(Predicted) |
storage temp. | −20°C |
solubility | Chloroform (Slightly), Methanol (Slightly) |
form | White solid. |
pka | 12.69±0.60(Predicted) |
color | Off-White to Yellow |
Safety information for BIS(METHYLTHIO)GLIOTOXIN
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P270:Do not eat, drink or smoke when using this product. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P312:Call a POISON CENTER or doctor/physician if you feel unwell. P330:Rinse mouth. P363:Wash contaminated clothing before reuse. P302+P352:IF ON SKIN: wash with plenty of soap and water. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P403:Store in a well-ventilated place. |
Computed Descriptors for BIS(METHYLTHIO)GLIOTOXIN
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