Bis-Propargyl-PEG13
- CAS NO.：1351373-50-6
- Empirical Formula: C30H54O13
- Molecular Weight: 622.74
- MDL number: MFCD31811435
- Update Date: 2023-04-23 13:52:06
What is Bis-Propargyl-PEG13?
Description
Bis-propargyl-PEG13 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
in vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
structure and hydrogen bonding
Bis-propargyl-PEG13 comprises two propargyl groups which can form triazole linkages with azide-bearing compounds or biomolecules in copper catalyzed Click Chemistry reactions. The hydrophilic PEG units help improve the solubility of the molecule in aqueous media.
Properties of Bis-Propargyl-PEG13
| solubility | Soluble in Water, DMSO, DMF, DCM |
Safety information for Bis-Propargyl-PEG13
Computed Descriptors for Bis-Propargyl-PEG13
New Products
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