BIS-(3,4,5-TRIMETHOXYPHENYL)-1,3-DIOXOLANE
- CAS NO.:116673-45-1
- Empirical Formula: C21H26O8
- Molecular Weight: 406.43
- MDL number: MFCD00155367
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-21 10:59:17
What is BIS-(3,4,5-TRIMETHOXYPHENYL)-1,3-DIOXOLANE?
The Uses of BIS-(3,4,5-TRIMETHOXYPHENYL)-1,3-DIOXOLANE
A potent and selective platlet activating factor
What are the applications of Application
(±) trans-2,5-Bis(3,4,5-trimethoxyphenyl)-1,3-dioxolane is a potent PAF-R antagonist
Biological Activity
(±)trans-2,5-bis-(3,4,5-trimethoxyphenyl)-1,3-dioxolane, also known as trans-btp dioxolane, is a paf receptor antagonist [1].platelet activating factor (paf), a phospholipid mediator of inflammation, is secreted by several cell types including arterial endothelial cells, and can activate polymorphonuclear leucocytes and monocytes via specific cell surface receptors. paf also stimulates the production of active oxygen species by human monocyte - derived macrophages. paf play important roles in a variety of pathophysiological states including acute allergy, inflammation, asthma, gastrointestinal ulceration, and toxic shock [1].(±)trans-2,5-bis-(3,4,5-trimethoxyphenyl)-1,3-dioxolane is a paf receptor antagonist. in the rabbit washed platelet assay, (±)trans-2,5-bis-(3,4,5-trimethoxyphenyl)-1,3-dioxolane showed good competitive paf antagonism with ki value of 0.3 μm, whereas the cis-isomer was much less active.
References
[1]. corey, e.j.,chen, c.p., and parry, m.j. dual binding modes to the receptor for platelet activating factor (paf) of anti-paf trans-2,5-diarylfurans. tetrahedron letters 29, 2899-2902 (1988).
Properties of BIS-(3,4,5-TRIMETHOXYPHENYL)-1,3-DIOXOLANE
Boiling point: | 508.3±50.0 °C(Predicted) |
Density | 1.184±0.06 g/cm3(Predicted) |
storage temp. | Store at -20°C |
solubility | ≤35mg/ml in ethanol;50mg/ml in DMSO;50mg/ml in dimethyl formamide |
form | White to off-white solid. |
Safety information for BIS-(3,4,5-TRIMETHOXYPHENYL)-1,3-DIOXOLANE
Computed Descriptors for BIS-(3,4,5-TRIMETHOXYPHENYL)-1,3-DIOXOLANE
New Products
Tubulysin G Tubulysin F 2,2-diethoxyethanethioamide Tubulysin B Potassium HMDS (1.0 M in THF) 3-N-BOC-(S)-AMINO BUTYRONITRILE 4-Methylenepiperidine HCl tert-Butyl (azetidin-3-yl)carbamate hydrochloride Methyl (R)-1-Boc-4,4-difluoropyrrolidine-2-carboxylate 3-Aminocyclobutanone hydrochloride (S)-3-Aminobutanenitrile hydrochloride 5-Piperazin-1-yl- benzofuran-2- carboxylic acid ethyl ester. HCl 2-Bromo-6- nitroanisole 2,3-dichloro-6- nitrobenzonitrile (S)-3-(3-fluoro- 4-thiomorpholinophenyl) -4-(hydroxymethyl) oxazolidin-2-one (2,3-Dihydro- benzofuran-5-yl)- ethanol 2,3-Dichloro-6- nitrobenzylamine Hydrochloride 7-Methoxyquinoline-4-carboxylic acid 7-Methoxyquinoline-4-carbonitrile 1H-Imidazole-4-carbonitrile (R)-methyl 2-formamido-3-(tritylthio)propanoate (R)-methyl 2-isocyano-3-(tritylthio)propanoate Salbutamol EP Impurity K / Salbutamol BP Impurity K Sertraline EP Impurity B / Sertraline BP Impurity B / 3,4-Dideschloro Sertraline HCl (USP) / cis-3,4-Dideschloro Sertraline HCl / Sertraline Phenyl ImpurityRelated products of tetrahydrofuran
You may like
-
3-(4-Chloro-butyryl) -1H-indole-5- carbonitrileView Details
276863-95-7 -
Ethyl 5-Aminobenzofuran-2- CarboxylateView Details
174775-48-5 -
5-(piperazin-1-yl) benzofuran-2- carboxamideView Details
183288-46-2 -
BenzofuranView Details
271-89-6 -
(2,3-Dihydro- benzofuran-5-yl)- ethanolView Details
87776-76-9 -
3-(S)-(+)- (1-Cyano-1,1- diphenylmethyl)- 1-tosylpyrrolidineView Details
133099-09-9 -
2,3-dichloro-6- nitrobenzonitrileView Details
2112-23-2 -
2,3-Dichloro-6- nitrobenzylamine HydrochlorideView Details
70380-49-3