Biphenylindanone A

Synonym(s):3′-[[(2-cyclopentyl-6,7-dimethyl-1-oxo-2,3-dihydro-1H-inden-5-yl)oxy]methyl]biphenyl-4-carboxylic acid;BINA;BINA - CAS 866823-73-6 - Calbiochem;Biphenylindanone A;Biphenyl-indanone A

CAS NO.：866823-73-6
Empirical Formula: C30H30O4
Molecular Weight: 454.56
MDL number: MFCD19440914
SAFETY DATA SHEET (SDS)
Update Date: 2024-10-23 13:36:13

What is Biphenylindanone A?

Description

The metabotropic glutamate receptor 2 (mGluR2) is a G_i/o-coupled receptor which is expressed on presynaptic nerve terminals and modulates the release of neurotransmitters like glutamate and GABA. Biphenylindanone A (BINA) is a positive allosteric modulator of mGluR2, stimulating the human and rat receptors with EC₅₀ values of 33.2 and 96 nM, respectively. It has no effect on glutamate-induced activation of other mGluR types. BINA can be used on cells, tissues, or animals. Because of its selectivity for mGluR2, robust in vivo activity, and brain penetrance, BINA can be used to elucidate the role of mGluR2 in such diverse processes as psychosis, schizophrenia, and drug addiction.

The Uses of Biphenylindanone A

Biphenylindanone A is an orally active metabotropic glutamate subtype 2 receptor positive allosteric modulator.

What are the applications of Application

BINA is a selective positive allosteric modulator of mGluR-2

Definition

ChEBI: Biphenylindanone a is a member of biphenyls.

storage

Room temperature (desiccate)

Properties of Biphenylindanone A

Melting point:	238-241℃
Boiling point:	676.9±55.0 °C(Predicted)
Density	1.220
storage temp.	Desiccate at RT
solubility	DMSO: ≥18mg/mL
pka	4.17±0.10(Predicted)
form	powder
color	white to tan

Safety information for Biphenylindanone A

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for Biphenylindanone A

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