Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1S,2S,5R,6S)- (9CI)
Synonym(s):(1S,2S,5R,6S)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxy lic acid, Eglumegad, Eglumetad;LY 354740 - CAS 176199-48-7 - Calbiochem
- CAS NO.：176199-48-7
- Empirical Formula: C8H11NO4
- Molecular Weight: 185.18
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-02 08:55:12
![Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1S,2S,5R,6S)- (9CI) Structural](https://img.chemicalbook.in/CAS/GIF/176199-48-7.gif)
What is Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1S,2S,5R,6S)- (9CI)?
The Uses of Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1S,2S,5R,6S)- (9CI)
Treatment ofgeneral anxiety disorders and smoking cessation (metabotropic glutamate agonist).
The Uses of Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1S,2S,5R,6S)- (9CI)
LY 354740 is a highly selective and potent agonist of group II mGluR.
What are the applications of Application
LY 354740 is a highly selective and potent agonist of group II mGluR
Definition
ChEBI: Eglumetad is a L-alpha-amino acid.
Biological Activity
Highly selective and potent agonist of group II mGlu receptors (EC 50 values are 5.1 and 24.3 nM at mGlu 2 and mGlu 3 receptors respectively and > 100000 nM at mGlu 4 , mGlu 7 , mGlu 1a and mGlu 5a receptors). Displays antianxiety and antiaddictive activity in vivo . Orally and systemically active.
storage
+4°C
Properties of Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1S,2S,5R,6S)- (9CI)
| Melting point: | 270-271 °C |
| Boiling point: | 376.4±32.0 °C(Predicted) |
| Density | 1.569 |
| storage temp. | Keep in dark place,Sealed in dry,2-8°C |
| solubility | H2O : 6.33 mg/mL (34.18 mM; Need ultrasonic and warming) |
| form | Powder |
| pka | 2.06±0.40(Predicted) |
| color | White to off-white |
Safety information for Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1S,2S,5R,6S)- (9CI)
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1S,2S,5R,6S)- (9CI)
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