4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline

CAS NO.：190728-25-7
Empirical Formula: C17H16N2O3
Molecular Weight: 296.32
MDL number: MFCD19685633
SAFETY DATA SHEET (SDS)
Update Date: 2023-12-26 17:07:23

What is 4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline?

The Uses of 4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline

4-(6,7-Dimethoxy-Quinolin-4-Yloxy)-Phenylamine is used in preparation of Cabozantinib Defluorination impurity.

Chemical Reactivity

4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline is a primary alcohol that has been shown to catalyze the reaction of potassium carbonate with an alkali metal hydroxide to produce potassium. It has also been shown to be a base catalyst for the reaction of cyclopropanecarboxylic acid with an alcohol ester to produce high yield.

Properties of 4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline

Melting point:	211.0 to 215.0 °C
Boiling point:	481.8±45.0 °C(Predicted)
Density	1.246±0.06 g/cm3 (20 ºC 760 Torr)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	DMSO (Slightly, Sonicated), Methanol (Slightly)
form	powder to crystal
pka	6.79±0.30(Predicted)
color	Light yellow to Brown
InChI	InChI=1S/C17H16N2O3/c1-20-16-9-13-14(10-17(16)21-2)19-8-7-15(13)22-12-5-3-11(18)4-6-12/h3-10H,18H2,1-2H3

Safety information for 4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention.