BAM-22P
- CAS NO.:76622-26-9
- Empirical Formula: C130H184N38O31S2
- Molecular Weight: 2839.22
- MDL number: MFCD00076690
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-08 21:13:59
What is BAM-22P?
Biological Activity
bovine adrenal medulla 22 peptide (bam22p) is a peptide with 22 amino acids which is one of the cleavage products of proenkephalin a, the precursor of leu- and met-enkephalin, in the adrenal medulla, with very potent opiate activity.
in vitro
in the guinea-pig ileum assay, bam-22p has been shown to have typical and extraordinarily potent opioid activities antagonized by naloxone. the potency of bam-22p is 26 times that of met-enkephalin and 22 times that of b hendorphin. ic50 value of bam-22p in this tissue, 1.3 nm, makes it the most potent met-enkephalin relatives that discoveried so far. [1].
in vivo
intrathecal (i.t.) administration of bam22 decreased nocifensive behavior scores, which measured as the sum of flinching and lifting/licking, in the first and second phases of the formalin test. such decrease was partially attenuated by systemic injection of naloxone. [2].
References
[1] mizuno k, minamino n, kangawa k, matsuo h. a new family of endogenous "big" met-enkephalins from bovine adrenal medulla: purification and structure of docosa- (bam-22p) and eicosapeptide (bam-20p) with very potent opiate activity. biochem biophys res commun. 1980 dec 31;97(4):1283-90.
[2] hong y, dai p, jiang j, zeng x. dual effects of intrathecal bam22 on nociceptive responses in acute and persistent pain--potential function of a novel receptor. br j pharmacol. 2004 feb;141(3):423-30.
Properties of BAM-22P
Density | 1.50±0.1 g/cm3(Predicted) |
RTECS | SC6200500 |
storage temp. | -15°C |
solubility | Soluble to 1 mg/ml in H2O |
form | Lyophilized solid |
Water Solubility | Soluble to 1 mg/ml in water |
Safety information for BAM-22P
Computed Descriptors for BAM-22P
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