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HomeProduct name listBAM-22P

BAM-22P

  • CAS NO.:76622-26-9
  • Empirical Formula: C130H184N38O31S2
  • Molecular Weight: 2839.22
  • MDL number: MFCD00076690
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-08 21:13:59
BAM-22P Structural

What is BAM-22P?

Biological Activity

bovine adrenal medulla 22 peptide (bam22p) is a peptide with 22 amino acids which is one of the cleavage products of proenkephalin a, the precursor of leu- and met-enkephalin, in the adrenal medulla, with very potent opiate activity.

in vitro

in the guinea-pig ileum assay, bam-22p has been shown to have typical and extraordinarily potent opioid activities antagonized by naloxone. the potency of bam-22p is 26 times that of met-enkephalin and 22 times that of b hendorphin. ic50 value of bam-22p in this tissue, 1.3 nm, makes it the most potent met-enkephalin relatives that discoveried so far. [1].

in vivo

intrathecal (i.t.) administration of bam22 decreased nocifensive behavior scores, which measured as the sum of flinching and lifting/licking, in the first and second phases of the formalin test. such decrease was partially attenuated by systemic injection of naloxone. [2].

References

[1] mizuno k, minamino n, kangawa k, matsuo h. a new family of endogenous "big" met-enkephalins from bovine adrenal medulla: purification and structure of docosa- (bam-22p) and eicosapeptide (bam-20p) with very potent opiate activity. biochem biophys res commun. 1980 dec 31;97(4):1283-90.
[2] hong y, dai p, jiang j, zeng x. dual effects of intrathecal bam22 on nociceptive responses in acute and persistent pain--potential function of a novel receptor. br j pharmacol. 2004 feb;141(3):423-30.

Properties of BAM-22P

Density  1.50±0.1 g/cm3(Predicted)
RTECS  SC6200500
storage temp.  -15°C
solubility  Soluble to 1 mg/ml in H2O
form  Lyophilized solid
Water Solubility  Soluble to 1 mg/ml in water

Safety information for BAM-22P

Computed Descriptors for BAM-22P

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