Baclofen-d4
- CAS NO.:1189938-30-4
- Empirical Formula: C10H8D4ClNO2
- Molecular Weight: 217.685427112
- Update Date: 2024-10-28 16:48:35
What is Baclofen-d4?
The Uses of Baclofen-d4
Specific GABA-B receptor agonist. Muscle relaxant (skeletal).
What are the applications of Application
Baclofen-d4 is a specific GABA-B receptor agonist
Biological Activity
(±)-Baclofen-d4 is intended for use as an internal standard for the quantification of (±)-baclofen by GC- or LC-MS. (±)-Baclofen is a GABAB receptor agonist (IC50 = 180 nM).1 It induces norepinephrine release from isolated rat atria (IC50 = 4.5 μM). (±)-Baclofen (10 mg/kg) increases muscle rigidity in spastic mice.2 It inhibits the norepinephrine-induced group II flexor reflex in anesthetized rats.3 (±)-Baclofen also reduces cocaine-induced hyperlocomotion in rats and binge-like ethanol intake in mice.4,5 Formulations containing baclofen have been used to treat muscle spasms caused by multiple sclerosis and spinal cord injury.
References
1.Hill, D.R., and Bowery, N.G.3H-baclofen and 3H-GABA bind to bicuculline-insensitive GABAB sites in rat brainNature290(5802)(1981) 2.Biscoe, T.J., and Fry, J.P.Some pharmacological studies on the spastic mouseBr. J. Pharmacol. 75(1)23-25(1982) 3.Sakitani, K.The effects of centrally acting muscle relaxants on the intrathecal noradrenaline-induced facilitation of the flexor reflex mediated by group II afferent fibers in ratsJpn. J. Pharmacol.63(3)369-376(1993) 4.Lhuillier, L., Mombereau, C., Cryan, J.F., et al.GABAB receptor-positive modulation decreases selective molecular and behavioral effects of cocaineNeuropsychopharmacology32(2)388-398(2007) 5.Moore, E.M., and Boehm, S.L., IISite-specific microinjection of baclofen into the anterior ventral tegmental area reduces binge-like ethanol intake in male C57BL/6J miceBehav. Neurosci.123(3)555-563(2009)
Properties of Baclofen-d4
storage temp. | Store at -20°C |
solubility | Water: soluble |
form | A solid |
color | White to off-white |
Water Solubility | Water: soluble |
Safety information for Baclofen-d4
Computed Descriptors for Baclofen-d4
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