B-D-GLUCOPYRANOSE
- CAS NO.:60976-49-0
- Empirical Formula: C41H28O27
- Molecular Weight: 952.64
- MDL number: MFCD09038731
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-18 11:31:04
What is B-D-GLUCOPYRANOSE?
Description
Geraniin is a tannin that has been found in P. urinaria and has diverse biological activities. It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; IC50s = 0.92 and 1.27 μM at pH 4.5 and 7.9, respectively), superoxide (IC50 = 2.65 μM), and hydroxyl radicals (IC50 = 1.44 μM) in cell-free assays. Geraniin inhibits herpes simplex virus 1 (HSV-1) and HSV-2 replication in plaque reduction assays (IC50s = 35 and 18.4 μM, respectively). It inhibits angiotensin-converting enzyme (ACE) in vitro (IC50 = 13.22 μM) and reduces both systolic and diastolic blood pressure in spontaneously hypertensive rats when administered at a dose of 5 mg/kg. Geraniin (5, 10, and 20 μM) induces apoptosis and halts the cell cycle at the S phase in A549 lung cancer cells. It reduces tumor growth in an A549 mouse xenograft model when administered at doses of 10 and 20 mg/kg.
The Uses of B-D-GLUCOPYRANOSE
Geraniin protects PC12 cells against neuronal damage and may be used in the treatment of Alzheimer’s disease/ Also is an ACE inhibitor which is useful for hypertension treatment.
Definition
ChEBI: Geraniin is a tannin.
Properties of B-D-GLUCOPYRANOSE
Density | 2.25 |
storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
solubility | DMSO : 100 mg/mL (104.97 mM; Need ultrasonic) |
form | powder |
pka | 6.35±0.70(Predicted) |
color | Light yellow |
Safety information for B-D-GLUCOPYRANOSE
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for B-D-GLUCOPYRANOSE
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