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HomeProduct name listAzidoacetic acid NHS ester

Azidoacetic acid NHS ester

Synonym(s):(2,5-Dioxopyrrolidin-1-yl) 2-azidoacetate;1-[(Azidoacetyl)oxy]pyrrolidine-2,5-dione

Azidoacetic acid NHS ester Structural

What is Azidoacetic acid NHS ester?

Description

Azidoacetic acid NHS ester is a compound containing an azide group and an NHS ester. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules.

The Uses of Azidoacetic acid NHS ester

Azidoacetic acid NHS ester is a simple azido-containing reagent with an N-hydroxysuccinimide (NHS) ester that can be reacted with primary amines at pH 7-9 forming a stable amide bond. The azide allows for chemoselective ligation with an alkyne or cyclooctyne. It is generally used to functionalize amines and amino acids with azidoacetyl groups. It is generally used in click chemistry applications.

Properties of Azidoacetic acid NHS ester

Melting point: 132-133o C
storage temp.  -20°C
solubility  Chloroform (Slightly)
form  powder or crystals
color  White to Off-White

Safety information for Azidoacetic acid NHS ester

Signal word Danger
Pictogram(s)
ghs
Flame
Flammables
GHS02
GHS Hazard Statements H242:Self-reactive substances and mixtures; and Organic peroxides
Precautionary Statement Codes P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P234:Keep only in original container.
P235:Keep cool.
P240:Ground/bond container and receiving equipment.
P370+P378:In case of fire: Use … for extinction.
P403:Store in a well-ventilated place.

Computed Descriptors for Azidoacetic acid NHS ester

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